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Defecatory function in Parkinson's disease: response to apomorphine.
Ann Neurol. 1993 May; 33(5):490-3.AN

Abstract

We evaluated the effects of the dopaminergic agent apomorphine on defecation and anorectal function in patients with Parkinson's disease (PD). A gastrointestinal symptom survey, extrapyramidal assessment, defecating proctogram, and anorectal manometric study were performed in 8 subjects with PD. Basal studies showing abnormalities were repeated following apomorphine administration. Prior defecographic abnormalities were normalized following apomorphine injection in 1 of 3 subjects and significant improvements in manometric parameters were observed in all 5 subjects who underwent repeat anorectal manometry. We conclude that apomorphine can correct anorectal dysfunction in PD, and that these abnormalities may be a consequence of dopamine deficiency secondary to the PD process. These findings may also have therapeutic implications.

Authors+Show Affiliations

Section of Neurology, University of Nebraska Medical Center, Omaha 68198-2045.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8498826

Citation

Edwards, L L., et al. "Defecatory Function in Parkinson's Disease: Response to Apomorphine." Annals of Neurology, vol. 33, no. 5, 1993, pp. 490-3.
Edwards LL, Quigley EM, Harned RK, et al. Defecatory function in Parkinson's disease: response to apomorphine. Ann Neurol. 1993;33(5):490-3.
Edwards, L. L., Quigley, E. M., Harned, R. K., Hofman, R., & Pfeiffer, R. F. (1993). Defecatory function in Parkinson's disease: response to apomorphine. Annals of Neurology, 33(5), 490-3.
Edwards LL, et al. Defecatory Function in Parkinson's Disease: Response to Apomorphine. Ann Neurol. 1993;33(5):490-3. PubMed PMID: 8498826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Defecatory function in Parkinson's disease: response to apomorphine. AU - Edwards,L L, AU - Quigley,E M, AU - Harned,R K, AU - Hofman,R, AU - Pfeiffer,R F, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 490 EP - 3 JF - Annals of neurology JO - Ann. Neurol. VL - 33 IS - 5 N2 - We evaluated the effects of the dopaminergic agent apomorphine on defecation and anorectal function in patients with Parkinson's disease (PD). A gastrointestinal symptom survey, extrapyramidal assessment, defecating proctogram, and anorectal manometric study were performed in 8 subjects with PD. Basal studies showing abnormalities were repeated following apomorphine administration. Prior defecographic abnormalities were normalized following apomorphine injection in 1 of 3 subjects and significant improvements in manometric parameters were observed in all 5 subjects who underwent repeat anorectal manometry. We conclude that apomorphine can correct anorectal dysfunction in PD, and that these abnormalities may be a consequence of dopamine deficiency secondary to the PD process. These findings may also have therapeutic implications. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8498826/Defecatory_function_in_Parkinson's_disease:_response_to_apomorphine_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1993&volume=33&issue=5&spage=490 DB - PRIME DP - Unbound Medicine ER -