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Search for antifungal, molluscicidal and larvicidal compounds from African medicinal plants.
J Ethnopharmacol. 1993 Mar; 38(2-3):215-23.JE

Abstract

African medicinal plants provide a rich source of biologically-active natural products. By the use of simple bioassays in conjunction with an approach involving bioactivity guided fractionation, it is possible to isolate novel compounds with interesting properties. Several hundred plant extracts have been submitted to different screens, including bioautography on TLC plates with the fungi Cladosporium cucumerinum and Candida albicans. Among the other test systems are a bioassay for molluscicidal activity with the schistosomiasis-transmitting snail Biomphalaria glabrata and a benchtop assay for larvicidal activity with larvae of the mosquito Aedes aegypti, the vector of yellow fever. Using a variety of modern separation techniques, a number of compounds with activity in these bioassays have been isolated. These include prenylated xanthones, tetracyclic phenols and saponins. The role of saponins and saponin-containing plants in the control of schistosomiasis is outlined.

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Authors+Show Affiliations

Marston A
Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Switzerland.
Maillard M
No affiliation info available
Hostettmann K
No affiliation info available

MeSH

AnimalsAntifungal AgentsInsecticidesLarvaMedicine, African TraditionalMolluscacidesPlants, Medicinal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8510471

Citation

Marston, A, et al. "Search for Antifungal, Molluscicidal and Larvicidal Compounds From African Medicinal Plants." Journal of Ethnopharmacology, vol. 38, no. 2-3, 1993, pp. 215-23.
Marston A, Maillard M, Hostettmann K. Search for antifungal, molluscicidal and larvicidal compounds from African medicinal plants. J Ethnopharmacol. 1993;38(2-3):215-23.
Marston, A., Maillard, M., & Hostettmann, K. (1993). Search for antifungal, molluscicidal and larvicidal compounds from African medicinal plants. Journal of Ethnopharmacology, 38(2-3), 215-23.
Marston A, Maillard M, Hostettmann K. Search for Antifungal, Molluscicidal and Larvicidal Compounds From African Medicinal Plants. J Ethnopharmacol. 1993;38(2-3):215-23. PubMed PMID: 8510471.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Search for antifungal, molluscicidal and larvicidal compounds from African medicinal plants. AU - Marston,A, AU - Maillard,M, AU - Hostettmann,K, PY - 1993/3/1/pubmed PY - 1993/3/1/medline PY - 1993/3/1/entrez SP - 215 EP - 23 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 38 IS - 2-3 N2 - African medicinal plants provide a rich source of biologically-active natural products. By the use of simple bioassays in conjunction with an approach involving bioactivity guided fractionation, it is possible to isolate novel compounds with interesting properties. Several hundred plant extracts have been submitted to different screens, including bioautography on TLC plates with the fungi Cladosporium cucumerinum and Candida albicans. Among the other test systems are a bioassay for molluscicidal activity with the schistosomiasis-transmitting snail Biomphalaria glabrata and a benchtop assay for larvicidal activity with larvae of the mosquito Aedes aegypti, the vector of yellow fever. Using a variety of modern separation techniques, a number of compounds with activity in these bioassays have been isolated. These include prenylated xanthones, tetracyclic phenols and saponins. The role of saponins and saponin-containing plants in the control of schistosomiasis is outlined. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/8510471/Search_for_antifungal_molluscicidal_and_larvicidal_compounds_from_African_medicinal_plants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-8741(93)90019-2 DB - PRIME DP - Unbound Medicine ER -