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Pigeon breeders' lung; IgG subclasses to pigeon intestinal mucin and IgA antigens.
Clin Exp Immunol. 1993 Jun; 92(3):494-9.CE

Abstract

Sera from all symptomatics with pigeon breeders' lung and many non-symptomatic pigeon breeders react specifically with the pigeon antigens and in particular pigeon intestinal secretions and isolated pigeon intestinal mucin and IgA. In sera from all 82 precipitin-positive pigeon breeders investigated, IgG1 reacted with both IgA and mucin, while IgG2 reacted predominantly with mucin only. Sera from all 32 symptomatic patients with pigeon breeders' lung demonstrated an IgG3 reaction with mucin, but only three sera showed reactivity against IgA and this was very weak. In contrast, only three out of 27 pigeon breeders with pulmonary pathology other than pigeon breeders' lung and only three out of 23 sera from healthy pigeon breeders showed detectable IgG3 reactivity with mucin. IgG4 from eight sera only reacted with mucin (n = 7) or IgA (n = 1) and showed no consistent pattern between subject groups. Precipitin-negative sera from 30 volunteers with no previous pigeon exposure showed no IgG subclass reactivity with either the pigeon intestinal secretions or the isolated mucin and IgA antigens. These results show specific IgG2 and IgG3 subclass reactivity to pigeon intestinal mucin antigen in precipitin-positive sera from pigeon breeders. Further IgG3 subclass reactivity specific to pigeon mucin is strongly associated with sera from patients with the active pigeon breeders' lung disease.

Authors+Show Affiliations

Public Health Laboratory, Cumberland Infirmary, Carlisle, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8513581

Citation

Todd, A, et al. "Pigeon Breeders' Lung; IgG Subclasses to Pigeon Intestinal Mucin and IgA Antigens." Clinical and Experimental Immunology, vol. 92, no. 3, 1993, pp. 494-9.
Todd A, Coan R, Allen A. Pigeon breeders' lung; IgG subclasses to pigeon intestinal mucin and IgA antigens. Clin Exp Immunol. 1993;92(3):494-9.
Todd, A., Coan, R., & Allen, A. (1993). Pigeon breeders' lung; IgG subclasses to pigeon intestinal mucin and IgA antigens. Clinical and Experimental Immunology, 92(3), 494-9.
Todd A, Coan R, Allen A. Pigeon Breeders' Lung; IgG Subclasses to Pigeon Intestinal Mucin and IgA Antigens. Clin Exp Immunol. 1993;92(3):494-9. PubMed PMID: 8513581.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pigeon breeders' lung; IgG subclasses to pigeon intestinal mucin and IgA antigens. AU - Todd,A, AU - Coan,R, AU - Allen,A, PY - 1993/6/1/pubmed PY - 1993/6/1/medline PY - 1993/6/1/entrez SP - 494 EP - 9 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 92 IS - 3 N2 - Sera from all symptomatics with pigeon breeders' lung and many non-symptomatic pigeon breeders react specifically with the pigeon antigens and in particular pigeon intestinal secretions and isolated pigeon intestinal mucin and IgA. In sera from all 82 precipitin-positive pigeon breeders investigated, IgG1 reacted with both IgA and mucin, while IgG2 reacted predominantly with mucin only. Sera from all 32 symptomatic patients with pigeon breeders' lung demonstrated an IgG3 reaction with mucin, but only three sera showed reactivity against IgA and this was very weak. In contrast, only three out of 27 pigeon breeders with pulmonary pathology other than pigeon breeders' lung and only three out of 23 sera from healthy pigeon breeders showed detectable IgG3 reactivity with mucin. IgG4 from eight sera only reacted with mucin (n = 7) or IgA (n = 1) and showed no consistent pattern between subject groups. Precipitin-negative sera from 30 volunteers with no previous pigeon exposure showed no IgG subclass reactivity with either the pigeon intestinal secretions or the isolated mucin and IgA antigens. These results show specific IgG2 and IgG3 subclass reactivity to pigeon intestinal mucin antigen in precipitin-positive sera from pigeon breeders. Further IgG3 subclass reactivity specific to pigeon mucin is strongly associated with sera from patients with the active pigeon breeders' lung disease. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/8513581/Pigeon_breeders'_lung L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9104&date=1993&volume=92&issue=3&spage=494 DB - PRIME DP - Unbound Medicine ER -