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Fasting plasma lipids, lipoproteins and apolipoproteins in Nigerian women using combined oral and progestin-only injectable contraceptives.

Abstract

Fasting plasma lipid, lipoprotein, and apolipoprotein (apo) profiles were determined in Nigerian women using a low-dose combined oral (Lo-Feminal + Fe) (n = 18), a progestin-only injectable (Depo-Provera) (n = 16) contraceptives and matched controls (n = 18). The mean of plasma total and low-density lipoprotein (LDL) cholesterol, apo B and Lp(a) were significantly higher (p < 0.01) in women using contraceptives than the controls. The mean of total and LDL-cholesterol and apo B were also significantly higher in the oral contraceptive users than those on progestin-only injectables. Furthermore, the mean of cardiovascular disease (CVD) risk indices, total/HDL-cholesterol (p < 0.05) and LDL/HDL-cholesterol (p < 0.01), were significantly higher in women on oral contraceptives than the controls. There were no statistically significant differences between the indices in the women using progestin-only injectables and the controls. Based on this finding, it is concluded that the use of steroidal contraceptives is associated with alterations of lipid and apolipoprotein profiles in Nigerian women and that the use of low-dose combined oral contraceptives may be associated with an increased CVD risk.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Christ Hospital Cardiovascular Research Center, Division of Lipid Metabolism and Preventive Atherosclerosis, Cincinnati, OH 45219.

    Source

    Contraception 47:5 1993 May pg 445-54

    MeSH

    Adult
    Analysis of Variance
    Apolipoprotein A-I
    Apolipoproteins
    Apolipoproteins B
    Blood Pressure
    Cardiovascular Diseases
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Contraceptives, Oral, Combined
    Ethinyl Estradiol
    Female
    Humans
    Lipids
    Lipoproteins
    Medroxyprogesterone Acetate
    Nigeria
    Norgestrel
    Risk Factors

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8513671

    Citation

    Oyelola, O O.. "Fasting Plasma Lipids, Lipoproteins and Apolipoproteins in Nigerian Women Using Combined Oral and Progestin-only Injectable Contraceptives." Contraception, vol. 47, no. 5, 1993, pp. 445-54.
    Oyelola OO. Fasting plasma lipids, lipoproteins and apolipoproteins in Nigerian women using combined oral and progestin-only injectable contraceptives. Contraception. 1993;47(5):445-54.
    Oyelola, O. O. (1993). Fasting plasma lipids, lipoproteins and apolipoproteins in Nigerian women using combined oral and progestin-only injectable contraceptives. Contraception, 47(5), pp. 445-54.
    Oyelola OO. Fasting Plasma Lipids, Lipoproteins and Apolipoproteins in Nigerian Women Using Combined Oral and Progestin-only Injectable Contraceptives. Contraception. 1993;47(5):445-54. PubMed PMID: 8513671.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fasting plasma lipids, lipoproteins and apolipoproteins in Nigerian women using combined oral and progestin-only injectable contraceptives. A1 - Oyelola,O O, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez KW - Africa KW - Africa South Of The Sahara KW - Biology KW - Blood Proteins KW - Cardiovascular Effects KW - Case Control Studies KW - Cholesterol KW - Clinical Research KW - Comparative Studies KW - Contraception KW - Contraception Research KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods--side effects KW - Depo-provera KW - Developing Countries KW - English Speaking Africa KW - Ethinyl Estradiol KW - Evaluation KW - Family Planning KW - Hemic System KW - Ingredients And Chemicals KW - Injectables--side effects KW - Inorganic Chemicals KW - Iron KW - Levonorgestrel KW - Lipid Metabolic Effects KW - Lipids KW - Medroxyprogesterone Acetate KW - Metals KW - Nigeria KW - Oral Contraceptives, Combined--side effects KW - Oral Contraceptives, Low-dose--side effects KW - Oral Contraceptives--side effects KW - Physiology KW - Research Methodology KW - Risk Assessment KW - Studies KW - Western Africa SP - 445 EP - 54 JF - Contraception JO - Contraception VL - 47 IS - 5 N2 - Fasting plasma lipid, lipoprotein, and apolipoprotein (apo) profiles were determined in Nigerian women using a low-dose combined oral (Lo-Feminal + Fe) (n = 18), a progestin-only injectable (Depo-Provera) (n = 16) contraceptives and matched controls (n = 18). The mean of plasma total and low-density lipoprotein (LDL) cholesterol, apo B and Lp(a) were significantly higher (p < 0.01) in women using contraceptives than the controls. The mean of total and LDL-cholesterol and apo B were also significantly higher in the oral contraceptive users than those on progestin-only injectables. Furthermore, the mean of cardiovascular disease (CVD) risk indices, total/HDL-cholesterol (p < 0.05) and LDL/HDL-cholesterol (p < 0.01), were significantly higher in women on oral contraceptives than the controls. There were no statistically significant differences between the indices in the women using progestin-only injectables and the controls. Based on this finding, it is concluded that the use of steroidal contraceptives is associated with alterations of lipid and apolipoprotein profiles in Nigerian women and that the use of low-dose combined oral contraceptives may be associated with an increased CVD risk. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/8513671/Fasting_plasma_lipids_lipoproteins_and_apolipoproteins_in_Nigerian_women_using_combined_oral_and_progestin_only_injectable_contraceptives_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0010-7824(93)90096-P DB - PRIME DP - Unbound Medicine ER -