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Pregnancy outcome and placental weights: their relationship to HIV-1 infection.
East Afr Med J. 1993 Feb; 70(2):85-9.EA

Abstract

The relationship between placental characteristics, including weight and inflammation, and pregnancy outcome was examined as part of a case control study looking into the impact of maternal HIV-1 infection on pregnancy outcome. Cases defined as low birth weight (< 2500g) or stillbirth deliveries, were compared to controls defined as mothers who delivered a live born neonate weighing 2500g or more. The mean placental weight and the mean foetal/placental weight ratio were significantly lower in cases (n = 253) than in controls (n = 216) (p < .05). Placental inflammation (chorioamnionitis) was significantly associated with prematurity (p < .001) and with stillbirth (p < .05), maternal HIV-1 antibody being a risk factor for chorioamnionitis in the preterm group. These data support a correlation between placental weight and pregnancy outcome, and suggest that maternal HIV-1 infection is a risk factor for chorioamnionitis in HIV-1 seropositive preterm deliveries.

Authors+Show Affiliations

Department of Human Pathology, University of Nairobi.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8513748

Citation

Gichangi, P B., et al. "Pregnancy Outcome and Placental Weights: Their Relationship to HIV-1 Infection." East African Medical Journal, vol. 70, no. 2, 1993, pp. 85-9.
Gichangi PB, Nyongo AO, Temmerman M. Pregnancy outcome and placental weights: their relationship to HIV-1 infection. East Afr Med J. 1993;70(2):85-9.
Gichangi, P. B., Nyongo, A. O., & Temmerman, M. (1993). Pregnancy outcome and placental weights: their relationship to HIV-1 infection. East African Medical Journal, 70(2), 85-9.
Gichangi PB, Nyongo AO, Temmerman M. Pregnancy Outcome and Placental Weights: Their Relationship to HIV-1 Infection. East Afr Med J. 1993;70(2):85-9. PubMed PMID: 8513748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pregnancy outcome and placental weights: their relationship to HIV-1 infection. AU - Gichangi,P B, AU - Nyongo,A O, AU - Temmerman,M, PY - 1993/2/1/pubmed PY - 1993/2/1/medline PY - 1993/2/1/entrez KW - Africa KW - Africa South Of The Sahara KW - Antibodies KW - Biology KW - Birth Weight KW - Body Weight KW - Case Control Studies KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Eastern Africa KW - English Speaking Africa KW - Fetal Death KW - Fetal Membranes KW - Fetus KW - Hiv Infections KW - Immunity KW - Immunologic Factors KW - Kenya KW - Low Birth Weight KW - Mortality KW - Physiology KW - Population KW - Population Dynamics KW - Pregnancy KW - Pregnancy Outcomes KW - Premature Birth KW - Reproduction KW - Research Methodology KW - Research Report KW - Risk Factors KW - Studies KW - Viral Diseases SP - 85 EP - 9 JF - East African medical journal JO - East Afr Med J VL - 70 IS - 2 N2 - The relationship between placental characteristics, including weight and inflammation, and pregnancy outcome was examined as part of a case control study looking into the impact of maternal HIV-1 infection on pregnancy outcome. Cases defined as low birth weight (< 2500g) or stillbirth deliveries, were compared to controls defined as mothers who delivered a live born neonate weighing 2500g or more. The mean placental weight and the mean foetal/placental weight ratio were significantly lower in cases (n = 253) than in controls (n = 216) (p < .05). Placental inflammation (chorioamnionitis) was significantly associated with prematurity (p < .001) and with stillbirth (p < .05), maternal HIV-1 antibody being a risk factor for chorioamnionitis in the preterm group. These data support a correlation between placental weight and pregnancy outcome, and suggest that maternal HIV-1 infection is a risk factor for chorioamnionitis in HIV-1 seropositive preterm deliveries. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/8513748/Pregnancy_outcome_and_placental_weights:_their_relationship_to_HIV_1_infection_ L2 - http://www.diseaseinfosearch.org/result/5922 DB - PRIME DP - Unbound Medicine ER -