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Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers.
Br J Surg. 1993 May; 80(5):596-9.BJ

Abstract

Urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA) were assayed in biopsies from the base, edge and adjacent skin of ischaemic and venous ulcers using a functional bioimmunoassay and a standard immunoassay. Two series of 14 biopsies were examined: from seven venous and seven ischaemic ulcers in the first series, eight venous and six ischaemic in the second. It was found that tPA was detected in only four samples of ulcer edge using the bioimmunoassay and in no sample by the standard immunoassay. By contrast, uPA was detected in all but one ulcer edge biopsy and at a significantly lower median concentration in the adjacent skin (16.9 units/g) than the ulcer edge (26.1 units/g) or base (32.3 units/g) (both P < 0.01). Levels of uPA were greater in the edge and base of venous compared with ischaemic ulcers. The predominant plasminogen activator in chronic leg ulcers is uPA; this activator may play an important role in wound healing.

Authors+Show Affiliations

Department of Surgery, St Thomas' Hospital, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8518896

Citation

Stacey, M C., et al. "Tissue and Urokinase Plasminogen Activators in the Environs of Venous and Ischaemic Leg Ulcers." The British Journal of Surgery, vol. 80, no. 5, 1993, pp. 596-9.
Stacey MC, Burnand KG, Mahmoud-Alexandroni M, et al. Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers. Br J Surg. 1993;80(5):596-9.
Stacey, M. C., Burnand, K. G., Mahmoud-Alexandroni, M., Gaffney, P. J., & Bhogal, B. S. (1993). Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers. The British Journal of Surgery, 80(5), 596-9.
Stacey MC, et al. Tissue and Urokinase Plasminogen Activators in the Environs of Venous and Ischaemic Leg Ulcers. Br J Surg. 1993;80(5):596-9. PubMed PMID: 8518896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers. AU - Stacey,M C, AU - Burnand,K G, AU - Mahmoud-Alexandroni,M, AU - Gaffney,P J, AU - Bhogal,B S, PY - 1993/5/1/pubmed PY - 1993/5/1/medline PY - 1993/5/1/entrez SP - 596 EP - 9 JF - The British journal of surgery JO - Br J Surg VL - 80 IS - 5 N2 - Urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA) were assayed in biopsies from the base, edge and adjacent skin of ischaemic and venous ulcers using a functional bioimmunoassay and a standard immunoassay. Two series of 14 biopsies were examined: from seven venous and seven ischaemic ulcers in the first series, eight venous and six ischaemic in the second. It was found that tPA was detected in only four samples of ulcer edge using the bioimmunoassay and in no sample by the standard immunoassay. By contrast, uPA was detected in all but one ulcer edge biopsy and at a significantly lower median concentration in the adjacent skin (16.9 units/g) than the ulcer edge (26.1 units/g) or base (32.3 units/g) (both P < 0.01). Levels of uPA were greater in the edge and base of venous compared with ischaemic ulcers. The predominant plasminogen activator in chronic leg ulcers is uPA; this activator may play an important role in wound healing. SN - 0007-1323 UR - https://www.unboundmedicine.com/medline/citation/8518896/Tissue_and_urokinase_plasminogen_activators_in_the_environs_of_venous_and_ischaemic_leg_ulcers_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0007-1323&amp;date=1993&amp;volume=80&amp;issue=5&amp;spage=596 DB - PRIME DP - Unbound Medicine ER -