Tags

Type your tag names separated by a space and hit enter

A secondary prevention trial of antioxidant vitamins and cardiovascular disease in women. Rationale, design, and methods. The WACS Research Group.
Ann Epidemiol 1995; 5(4):261-9AE

Abstract

The evidence for a potential benefit of antioxidant vitamins in the prevention and therapy of atherosclerotic disease is derived from laboratory, clinical, and observational epidemiologic studies but remains inconclusive. Data from randomized clinical trials are sparse, particularly for women. Therefore, it is both timely and important to conduct large-scale primary and secondary prevention trials of antioxidants and cardiovascular disease (CVD). The Women's Antioxidant and Cardiovascular Study (WACS) is a randomized, double-blind, placebo-controlled secondary prevention trial of the balance of benefits and risks of antioxidant vitamins (vitamins E and C, and beta-carotene) among 8000 women with preexisting CVD. This secondary prevention trial will be conducted as a companion to the recently started Women's Health Study, a primary prevention trial of vitamin E and beta-carotene, as well as aspirin. In the WACS, US female health professionals aged 40 years and older with a history of myocardial infarction, angina pectoris, coronary revascularization, stroke, transient cerebral ischemia, carotid endarterectomy, or peripheral artery surgery will be randomly assigned, utilizing a 2 x 2 x 2 factorial design, to receive vitamin E, vitamin C, beta-carotene, and/or placebo. Cardiovascular end points include nonfatal myocardial infarction, nonfatal stroke, coronary revascularization procedures, and total CVD mortality. The present article describes the rationale, design, and methods of the trial.

Authors+Show Affiliations

Department of Medicine, Harvard Medical School, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8520707

Citation

Manson, J E., et al. "A Secondary Prevention Trial of Antioxidant Vitamins and Cardiovascular Disease in Women. Rationale, Design, and Methods. the WACS Research Group." Annals of Epidemiology, vol. 5, no. 4, 1995, pp. 261-9.
Manson JE, Gaziano JM, Spelsberg A, et al. A secondary prevention trial of antioxidant vitamins and cardiovascular disease in women. Rationale, design, and methods. The WACS Research Group. Ann Epidemiol. 1995;5(4):261-9.
Manson, J. E., Gaziano, J. M., Spelsberg, A., Ridker, P. M., Cook, N. R., Buring, J. E., ... Hennekens, C. H. (1995). A secondary prevention trial of antioxidant vitamins and cardiovascular disease in women. Rationale, design, and methods. The WACS Research Group. Annals of Epidemiology, 5(4), pp. 261-9.
Manson JE, et al. A Secondary Prevention Trial of Antioxidant Vitamins and Cardiovascular Disease in Women. Rationale, Design, and Methods. the WACS Research Group. Ann Epidemiol. 1995;5(4):261-9. PubMed PMID: 8520707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A secondary prevention trial of antioxidant vitamins and cardiovascular disease in women. Rationale, design, and methods. The WACS Research Group. AU - Manson,J E, AU - Gaziano,J M, AU - Spelsberg,A, AU - Ridker,P M, AU - Cook,N R, AU - Buring,J E, AU - Willett,W C, AU - Hennekens,C H, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 261 EP - 9 JF - Annals of epidemiology JO - Ann Epidemiol VL - 5 IS - 4 N2 - The evidence for a potential benefit of antioxidant vitamins in the prevention and therapy of atherosclerotic disease is derived from laboratory, clinical, and observational epidemiologic studies but remains inconclusive. Data from randomized clinical trials are sparse, particularly for women. Therefore, it is both timely and important to conduct large-scale primary and secondary prevention trials of antioxidants and cardiovascular disease (CVD). The Women's Antioxidant and Cardiovascular Study (WACS) is a randomized, double-blind, placebo-controlled secondary prevention trial of the balance of benefits and risks of antioxidant vitamins (vitamins E and C, and beta-carotene) among 8000 women with preexisting CVD. This secondary prevention trial will be conducted as a companion to the recently started Women's Health Study, a primary prevention trial of vitamin E and beta-carotene, as well as aspirin. In the WACS, US female health professionals aged 40 years and older with a history of myocardial infarction, angina pectoris, coronary revascularization, stroke, transient cerebral ischemia, carotid endarterectomy, or peripheral artery surgery will be randomly assigned, utilizing a 2 x 2 x 2 factorial design, to receive vitamin E, vitamin C, beta-carotene, and/or placebo. Cardiovascular end points include nonfatal myocardial infarction, nonfatal stroke, coronary revascularization procedures, and total CVD mortality. The present article describes the rationale, design, and methods of the trial. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/8520707/A_secondary_prevention_trial_of_antioxidant_vitamins_and_cardiovascular_disease_in_women__Rationale_design_and_methods__The_WACS_Research_Group_ L2 - https://linkinghub.elsevier.com/retrieve/pii/1047279794000917 DB - PRIME DP - Unbound Medicine ER -