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Triglyceride uptake in muscles in rats.
Obes Res. 1995 Sep; 3(5):419-26.OR

Abstract

Exogenous lipid is assimilated with different priorities in adipose tissue regions and varies in the fasting and fed conditions. The quantitative role of uptake of lipid in muscle has not been evaluated. In order to examine the uptake in other than adipose tissues, U14C-oleic acid in sesame oil was administered orally to conscious rats, and lipid label measured after different times in serum, heart, liver, mesenteric, retroperitoneal, inguinal and epididymal fat pads, as well as in red and white parts of gastrocnemius, extensor digitorum longus and soleus muscles. Lipid uptake in total adipose tissue was calculated from dissected adipose tissues plus lipids extracted from the eviscerated, skinned carcass. Lipid uptake in total muscle tissue was estimated from label in dissected muscles plus that in the carcass, assuming similar intracellular lipid contents and radioactivity as that averaged from dissected muscles. Lipid uptake in the liver was calculated from directly extracted lipid. Four hours after lipid administration to fed rats lipid radioactivity in heart and serum was minimal and had essentially disappeared at 8 hours. Liver label declined rapidly from peak values at or before 4 hours. Adipose tissue radioactivity increased gradually up to 16 hours and then decreased. Label in muscles was highest at 4 hours in the red gastrocnemius, and then decreased, while the other muscles showed a constant radioactivity over the observation period (24 hours). Radioactivity expressed per unit muscle mass seemed to be proportional to the oxidative capacity of muscles.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Wallenberg Laboratory, Sahlgren's Hospital, University of Göteborg, Sweden.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8521161

Citation

Li, M, and P Björntorp. "Triglyceride Uptake in Muscles in Rats." Obesity Research, vol. 3, no. 5, 1995, pp. 419-26.
Li M, Björntorp P. Triglyceride uptake in muscles in rats. Obes Res. 1995;3(5):419-26.
Li, M., & Björntorp, P. (1995). Triglyceride uptake in muscles in rats. Obesity Research, 3(5), 419-26.
Li M, Björntorp P. Triglyceride Uptake in Muscles in Rats. Obes Res. 1995;3(5):419-26. PubMed PMID: 8521161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triglyceride uptake in muscles in rats. AU - Li,M, AU - Björntorp,P, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 419 EP - 26 JF - Obesity research JO - Obes. Res. VL - 3 IS - 5 N2 - Exogenous lipid is assimilated with different priorities in adipose tissue regions and varies in the fasting and fed conditions. The quantitative role of uptake of lipid in muscle has not been evaluated. In order to examine the uptake in other than adipose tissues, U14C-oleic acid in sesame oil was administered orally to conscious rats, and lipid label measured after different times in serum, heart, liver, mesenteric, retroperitoneal, inguinal and epididymal fat pads, as well as in red and white parts of gastrocnemius, extensor digitorum longus and soleus muscles. Lipid uptake in total adipose tissue was calculated from dissected adipose tissues plus lipids extracted from the eviscerated, skinned carcass. Lipid uptake in total muscle tissue was estimated from label in dissected muscles plus that in the carcass, assuming similar intracellular lipid contents and radioactivity as that averaged from dissected muscles. Lipid uptake in the liver was calculated from directly extracted lipid. Four hours after lipid administration to fed rats lipid radioactivity in heart and serum was minimal and had essentially disappeared at 8 hours. Liver label declined rapidly from peak values at or before 4 hours. Adipose tissue radioactivity increased gradually up to 16 hours and then decreased. Label in muscles was highest at 4 hours in the red gastrocnemius, and then decreased, while the other muscles showed a constant radioactivity over the observation period (24 hours). Radioactivity expressed per unit muscle mass seemed to be proportional to the oxidative capacity of muscles.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/8521161/Triglyceride_uptake_in_muscles_in_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1071-7323&date=1995&volume=3&issue=5&spage=419 DB - PRIME DP - Unbound Medicine ER -