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Stress signaling in yeast.
Bioessays. 1995 Nov; 17(11):959-65.B

Abstract

In the yeast Saccharomyces cerevisiae three positive transcriptional control elements are activated by stress conditions: heat shock elements (HSEs), stress response elements (STREs) and AP-1 responsive elements (AREs). HSEs bind heat shock transcription factor (HSF), which is activated by stress conditions causing accumulation of abnormal proteins. STREs mediate transcriptional activation by multiple stress conditions. They are controlled by high osmolarity via the HOG signal pathway, which comprises a MAP kinase module and a two-component system homologous to prokaryotic signal transducers. AREs bind the transcription factor Yap1p. The three types of control elements seem to have overlapping, but distinct functions. Some stress proteins encoded by HSE-regulated genes are necessary for growth of yeast under moderate stress, products of STRE-activated genes appear to be important for survival under severe stress and ARE-controlled genes may mainly function during oxidative stress and in the response to toxic conditions, such as caused by heavy metal ions.

Authors+Show Affiliations

Ruis H
Vienna Biocenter, Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Austria.
Schüller C
No affiliation info available

MeSH

Calcium-Calmodulin-Dependent Protein KinasesCyclic AMP-Dependent Protein KinasesGenes, FungalHeat-Shock ProteinsSaccharomyces cerevisiaeSignal TransductionTranscription Factor AP-1

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8526890

Citation

Ruis, H, and C Schüller. "Stress Signaling in Yeast." BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology, vol. 17, no. 11, 1995, pp. 959-65.
Ruis H, Schüller C. Stress signaling in yeast. Bioessays. 1995;17(11):959-65.
Ruis, H., & Schüller, C. (1995). Stress signaling in yeast. BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology, 17(11), 959-65.
Ruis H, Schüller C. Stress Signaling in Yeast. Bioessays. 1995;17(11):959-65. PubMed PMID: 8526890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stress signaling in yeast. AU - Ruis,H, AU - Schüller,C, PY - 1995/11/1/pubmed PY - 1995/11/1/medline PY - 1995/11/1/entrez SP - 959 EP - 65 JF - BioEssays : news and reviews in molecular, cellular and developmental biology JO - Bioessays VL - 17 IS - 11 N2 - In the yeast Saccharomyces cerevisiae three positive transcriptional control elements are activated by stress conditions: heat shock elements (HSEs), stress response elements (STREs) and AP-1 responsive elements (AREs). HSEs bind heat shock transcription factor (HSF), which is activated by stress conditions causing accumulation of abnormal proteins. STREs mediate transcriptional activation by multiple stress conditions. They are controlled by high osmolarity via the HOG signal pathway, which comprises a MAP kinase module and a two-component system homologous to prokaryotic signal transducers. AREs bind the transcription factor Yap1p. The three types of control elements seem to have overlapping, but distinct functions. Some stress proteins encoded by HSE-regulated genes are necessary for growth of yeast under moderate stress, products of STRE-activated genes appear to be important for survival under severe stress and ARE-controlled genes may mainly function during oxidative stress and in the response to toxic conditions, such as caused by heavy metal ions. SN - 0265-9247 UR - https://www.unboundmedicine.com/medline/citation/8526890/Stress_signaling_in_yeast_ L2 - https://doi.org/10.1002/bies.950171109 DB - PRIME DP - Unbound Medicine ER -