Tags

Type your tag names separated by a space and hit enter

Case-control study of oral contraceptive use and risk of breast cancer.
Am J Epidemiol 1996; 143(1):25-37AJ

Abstract

The relation of oral contraceptive use to the risk of breast cancer in white women aged 25-59 years was assessed with data collected during 1977-1992 in a case-control surveillance system in hospitals in Boston, New York, and Philadelphia. A total of 3,540 cases with breast cancer were compared with 4,488 controls with nonmalignant nongynecologic conditions unrelated to oral contraceptive use. Relative risk estimates were obtained by unconditional logistic regression with control for major risk factors. For at least 1 year of use relative to less than 1 year, the multivariate relative risk estimate was 1.7 (95% confidence interval (CI) 1.3-2.3) in women aged 25-34 years, 0.9 (95% CI 0.7-1.0) in women aged 35-44 years, and 1.2 (95% CI 1.0-1.4) in women aged 45-59 years (p < 0.01 for the difference across age). Among women aged 25-34 years, the relative risk estimates were greatest for use of long duration, but the trend was not statistically significant (p = 0.17); in addition, the duration of use was correlated with the recency of use, and it was not possible to distinguish their effects. Among women aged 35-44 years, the relative risk estimate decreased with increasing duration of use (p = 0.01). Among women aged 45-59 years, some relative risk estimates were increased, but there was no consistent pattern. The results add to the evidence of an association between oral contraceptive use and an increased risk of breast cancer at young ages.

Authors+Show Affiliations

Slone Epidemiology Unit, School of Public Health, Boston University School of Medicine, Brookline 02146, USA.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8533744

Citation

Rosenberg, L, et al. "Case-control Study of Oral Contraceptive Use and Risk of Breast Cancer." American Journal of Epidemiology, vol. 143, no. 1, 1996, pp. 25-37.
Rosenberg L, Palmer JR, Rao RS, et al. Case-control study of oral contraceptive use and risk of breast cancer. Am J Epidemiol. 1996;143(1):25-37.
Rosenberg, L., Palmer, J. R., Rao, R. S., Zauber, A. G., Strom, B. L., Warshauer, M. E., ... Shapiro, S. (1996). Case-control study of oral contraceptive use and risk of breast cancer. American Journal of Epidemiology, 143(1), pp. 25-37.
Rosenberg L, et al. Case-control Study of Oral Contraceptive Use and Risk of Breast Cancer. Am J Epidemiol. 1996 Jan 1;143(1):25-37. PubMed PMID: 8533744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case-control study of oral contraceptive use and risk of breast cancer. AU - Rosenberg,L, AU - Palmer,J R, AU - Rao,R S, AU - Zauber,A G, AU - Strom,B L, AU - Warshauer,M E, AU - Harlap,S, AU - Shapiro,S, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez KW - Age Factors KW - Americas KW - Biology KW - Breast Cancer KW - Cancer KW - Case Control Studies KW - Contraception KW - Contraceptive Methods KW - Correlation Studies KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Family Planning KW - Neoplasms KW - North America KW - Northern America KW - Oral Contraceptives KW - Population KW - Population Characteristics KW - Research Methodology KW - Risk Factors KW - Statistical Studies KW - Studies KW - United States SP - 25 EP - 37 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 143 IS - 1 N2 - The relation of oral contraceptive use to the risk of breast cancer in white women aged 25-59 years was assessed with data collected during 1977-1992 in a case-control surveillance system in hospitals in Boston, New York, and Philadelphia. A total of 3,540 cases with breast cancer were compared with 4,488 controls with nonmalignant nongynecologic conditions unrelated to oral contraceptive use. Relative risk estimates were obtained by unconditional logistic regression with control for major risk factors. For at least 1 year of use relative to less than 1 year, the multivariate relative risk estimate was 1.7 (95% confidence interval (CI) 1.3-2.3) in women aged 25-34 years, 0.9 (95% CI 0.7-1.0) in women aged 35-44 years, and 1.2 (95% CI 1.0-1.4) in women aged 45-59 years (p < 0.01 for the difference across age). Among women aged 25-34 years, the relative risk estimates were greatest for use of long duration, but the trend was not statistically significant (p = 0.17); in addition, the duration of use was correlated with the recency of use, and it was not possible to distinguish their effects. Among women aged 35-44 years, the relative risk estimate decreased with increasing duration of use (p = 0.01). Among women aged 45-59 years, some relative risk estimates were increased, but there was no consistent pattern. The results add to the evidence of an association between oral contraceptive use and an increased risk of breast cancer at young ages. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/8533744/Case_control_study_of_oral_contraceptive_use_and_risk_of_breast_cancer_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a008654 DB - PRIME DP - Unbound Medicine ER -