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Apolipoprotein (a) concentrations in type 1 (insulin-dependent) diabetes mellitus.
Rom J Intern Med. 1995 Jan-Jun; 33(1-2):77-83.RJ

Abstract

It has been suggested that insulin-dependent diabetes mellitus (IDDM) patients have higher values of lipoprotein (a)-Lp (a) that may account for their increased atherogenic risk, as related to non-diabetic subjects. We compared the plasma values of apolipoprotein (a)-(apo) (a) in type 1 diabetic patients (n = 26) hospitalized in our department and in non-diabetic subjects (n = 20) from Timişoara, Romania. IDDM patients had higher levels of apo (a) than controls [115(102-227) vs 58 (51-106) U/l; medians with 95% confidence intervals]; (p = 0.0083). Diabetes duration, the levels of hemoglobin A1 (Hb A1) and the values of body mass index (BMI) were not significantly related to apo(a) concentrations, while no correlations were found between apo (a) and plasma lipid values (total cholesterol (TC), low density lipoprotein cholesterol (LDLc), high density lipoprotein cholesterol (HDLc), triglyceride. A significant association was noticed between apo (a) and apo B both in IDDM patients (r = 0.43; 0.02 < p < 0.05), and in controls (r = 0.83; p < 0.001). We conclude that apo (a) levels are higher in IDDM patients than in non-diabetic subjects, but they are not related to the degree of glycemic control. Apo (a) and apo B are significantly correlated, both of them being well-known atherogenic risk factors.

Authors+Show Affiliations

Department of Diabetes, University for Medicine and Pharmacy, Timişoara, Romania.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8535356

Citation

Serban, V, et al. "Apolipoprotein (a) Concentrations in Type 1 (insulin-dependent) Diabetes Mellitus." Romanian Journal of Internal Medicine = Revue Roumaine De Medecine Interne, vol. 33, no. 1-2, 1995, pp. 77-83.
Serban V, Dabelea D, Deutsch G, et al. Apolipoprotein (a) concentrations in type 1 (insulin-dependent) diabetes mellitus. Rom J Intern Med. 1995;33(1-2):77-83.
Serban, V., Dabelea, D., Deutsch, G., Pataki, C., & Dan, I. (1995). Apolipoprotein (a) concentrations in type 1 (insulin-dependent) diabetes mellitus. Romanian Journal of Internal Medicine = Revue Roumaine De Medecine Interne, 33(1-2), 77-83.
Serban V, et al. Apolipoprotein (a) Concentrations in Type 1 (insulin-dependent) Diabetes Mellitus. Rom J Intern Med. 1995 Jan-Jun;33(1-2):77-83. PubMed PMID: 8535356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein (a) concentrations in type 1 (insulin-dependent) diabetes mellitus. AU - Serban,V, AU - Dabelea,D, AU - Deutsch,G, AU - Pataki,C, AU - Dan,I, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 77 EP - 83 JF - Romanian journal of internal medicine = Revue roumaine de medecine interne JO - Rom J Intern Med VL - 33 IS - 1-2 N2 - It has been suggested that insulin-dependent diabetes mellitus (IDDM) patients have higher values of lipoprotein (a)-Lp (a) that may account for their increased atherogenic risk, as related to non-diabetic subjects. We compared the plasma values of apolipoprotein (a)-(apo) (a) in type 1 diabetic patients (n = 26) hospitalized in our department and in non-diabetic subjects (n = 20) from Timişoara, Romania. IDDM patients had higher levels of apo (a) than controls [115(102-227) vs 58 (51-106) U/l; medians with 95% confidence intervals]; (p = 0.0083). Diabetes duration, the levels of hemoglobin A1 (Hb A1) and the values of body mass index (BMI) were not significantly related to apo(a) concentrations, while no correlations were found between apo (a) and plasma lipid values (total cholesterol (TC), low density lipoprotein cholesterol (LDLc), high density lipoprotein cholesterol (HDLc), triglyceride. A significant association was noticed between apo (a) and apo B both in IDDM patients (r = 0.43; 0.02 < p < 0.05), and in controls (r = 0.83; p < 0.001). We conclude that apo (a) levels are higher in IDDM patients than in non-diabetic subjects, but they are not related to the degree of glycemic control. Apo (a) and apo B are significantly correlated, both of them being well-known atherogenic risk factors. SN - 1220-4749 UR - https://www.unboundmedicine.com/medline/citation/8535356/Apolipoprotein__a__concentrations_in_type_1__insulin_dependent__diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/8214 DB - PRIME DP - Unbound Medicine ER -