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The effects of nomegestrol acetate subdermal implant (Uniplant) on carbohydrate metabolism, serum lipoproteins and on hepatic function in women.
Contraception. 1995 Aug; 52(2):111-4.C

Abstract

This study was undertaken to assess possible variations in body weight, blood pressure, fasting glucose, HbA1C, insulin, total cholesterol, HDL-C, LDL-C, triglycerides, SGPT, SGOT, GGT and bilirubin in women bearing a single subdermal Silastic implant containing 55 mg (10%) of nomegestrol acetate during two years. A total of eighteen volunteers of reproductive age who desired to avoid conception were enrolled in this study. Subjects were healthy women with no contraindications to hormonal contraception. All women were investigated before starting treatment and were followed up for one year. At the end of one year the capsules were removed and a new capsule was inserted. Fasting blood samples were drawn at 8:00 to 8:30 am twice prior to implant insertion and then at the first, third, sixth and twelfth months and every six months thereafter. Body weight increased from 54.9 +/- 1.5 kg at admission to 55.3 +/- 2.0 kg at 12 months of use (p < 0.05) and to 56.0 +/- 2.7 kg at 24 months of use. A slight increase in both systolic and diastolic blood pressure was recorded at month 12 (p < 0.01). At month 24, blood pressure was not significantly different from admission values. All levels were within the normal range. Insulin, HbA1C, LDL-C and GGT remained unchanged during twenty-four months of Uniplant use. A significant decrease in total cholesterol (p < 0.05) was observed in the third month while a significant decrease in HDL-C (p < 0.01) was observed only in the sixth month of Uniplant use.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Federal University of Bahia, Maternidade Climerio de Oliveira, Salvador, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8536447

Citation

Barbosa, I, et al. "The Effects of Nomegestrol Acetate Subdermal Implant (Uniplant) On Carbohydrate Metabolism, Serum Lipoproteins and On Hepatic Function in Women." Contraception, vol. 52, no. 2, 1995, pp. 111-4.
Barbosa I, Coutinho E, Athayde C, et al. The effects of nomegestrol acetate subdermal implant (Uniplant) on carbohydrate metabolism, serum lipoproteins and on hepatic function in women. Contraception. 1995;52(2):111-4.
Barbosa, I., Coutinho, E., Athayde, C., Ladipo, O., Olsson, S. E., & Ulmsten, U. (1995). The effects of nomegestrol acetate subdermal implant (Uniplant) on carbohydrate metabolism, serum lipoproteins and on hepatic function in women. Contraception, 52(2), 111-4.
Barbosa I, et al. The Effects of Nomegestrol Acetate Subdermal Implant (Uniplant) On Carbohydrate Metabolism, Serum Lipoproteins and On Hepatic Function in Women. Contraception. 1995;52(2):111-4. PubMed PMID: 8536447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of nomegestrol acetate subdermal implant (Uniplant) on carbohydrate metabolism, serum lipoproteins and on hepatic function in women. AU - Barbosa,I, AU - Coutinho,E, AU - Athayde,C, AU - Ladipo,O, AU - Olsson,S E, AU - Ulmsten,U, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez KW - Americas KW - Biology KW - Blood Pressure--changes KW - Body Weight--changes KW - Brazil KW - Carbohydrate Metabolic Effects KW - Cholesterol--changes KW - Clinical Research KW - Clinical Trials KW - Contraception KW - Contraceptive Implants KW - Contraceptive Methods KW - Developing Countries KW - Endocrine System KW - Family Planning KW - Hemic System KW - Hepatic Effects KW - Hormones KW - Latin America KW - Lipids KW - Metabolic Effects KW - Physiology KW - Progestational Hormones KW - Progesterone KW - Research Methodology KW - Research Report KW - South America SP - 111 EP - 4 JF - Contraception JO - Contraception VL - 52 IS - 2 N2 - This study was undertaken to assess possible variations in body weight, blood pressure, fasting glucose, HbA1C, insulin, total cholesterol, HDL-C, LDL-C, triglycerides, SGPT, SGOT, GGT and bilirubin in women bearing a single subdermal Silastic implant containing 55 mg (10%) of nomegestrol acetate during two years. A total of eighteen volunteers of reproductive age who desired to avoid conception were enrolled in this study. Subjects were healthy women with no contraindications to hormonal contraception. All women were investigated before starting treatment and were followed up for one year. At the end of one year the capsules were removed and a new capsule was inserted. Fasting blood samples were drawn at 8:00 to 8:30 am twice prior to implant insertion and then at the first, third, sixth and twelfth months and every six months thereafter. Body weight increased from 54.9 +/- 1.5 kg at admission to 55.3 +/- 2.0 kg at 12 months of use (p < 0.05) and to 56.0 +/- 2.7 kg at 24 months of use. A slight increase in both systolic and diastolic blood pressure was recorded at month 12 (p < 0.01). At month 24, blood pressure was not significantly different from admission values. All levels were within the normal range. Insulin, HbA1C, LDL-C and GGT remained unchanged during twenty-four months of Uniplant use. A significant decrease in total cholesterol (p < 0.05) was observed in the third month while a significant decrease in HDL-C (p < 0.01) was observed only in the sixth month of Uniplant use.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/8536447/The_effects_of_nomegestrol_acetate_subdermal_implant__Uniplant__on_carbohydrate_metabolism_serum_lipoproteins_and_on_hepatic_function_in_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010782495001441 DB - PRIME DP - Unbound Medicine ER -