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A comparison of 5 days of dirithromycin and 7 days of clarithromycin in acute bacterial exacerbation of chronic bronchitis.
J Antimicrob Chemother. 1995 Jul; 36(1):173-83.JA

Abstract

The safety and efficacy of dirithromycin and clarithromycin were compared in a single-blind, multicentre study of patients with acute bacterial exacerbation of chronic bronchitis (AECB). Patients received either dirithromycin, 500 mg once daily for 5 days, or clarithromycin, 250 mg twice daily for 7 days. A total of 212 patients entered the study, of whom 191 qualified for efficacy analysis. Favourable post-therapy clinical and bacteriological response rates for qualified patients (95 dirithromycin and 96 clarithromycin) were similar: 89.5% and 68.8% for dirithromycin vs 94.8% and 71.9% for clarithromycin. At late post-therapy evaluation, favourable clinical and bacteriological response rates were achieved in 98.8% and 96.2% of dirithromycin patients and 95.3% and 93.3% of clarithromycin patients, respectively. These differences were neither statistically nor clinically significantly different. Both drugs had similar efficacy against Haemophilus influenzae and both were well tolerated. Dirithromycin, administered as a single daily dose for just 5 days resulted in complete compliance in all but four patients. In clarithromycin-treated patients, requiring a 7-day course of twice-daily treatment, compliance was less satisfactory, with 12 patients failing to comply, though the between-group difference was not statistically significant. It can be concluded that 5 days of dirithromycin, 500 mg once daily is as safe and effective as 7 days of clarithromycin, 250 mg, twice daily in the treatment of AECB.

Authors+Show Affiliations

Health Centre, Sligo, Ireland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

8537264

Citation

Hosie, J, et al. "A Comparison of 5 Days of Dirithromycin and 7 Days of Clarithromycin in Acute Bacterial Exacerbation of Chronic Bronchitis." The Journal of Antimicrobial Chemotherapy, vol. 36, no. 1, 1995, pp. 173-83.
Hosie J, Quinn P, Smits P, et al. A comparison of 5 days of dirithromycin and 7 days of clarithromycin in acute bacterial exacerbation of chronic bronchitis. J Antimicrob Chemother. 1995;36(1):173-83.
Hosie, J., Quinn, P., Smits, P., & Sides, G. (1995). A comparison of 5 days of dirithromycin and 7 days of clarithromycin in acute bacterial exacerbation of chronic bronchitis. The Journal of Antimicrobial Chemotherapy, 36(1), 173-83.
Hosie J, et al. A Comparison of 5 Days of Dirithromycin and 7 Days of Clarithromycin in Acute Bacterial Exacerbation of Chronic Bronchitis. J Antimicrob Chemother. 1995;36(1):173-83. PubMed PMID: 8537264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of 5 days of dirithromycin and 7 days of clarithromycin in acute bacterial exacerbation of chronic bronchitis. AU - Hosie,J, AU - Quinn,P, AU - Smits,P, AU - Sides,G, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 173 EP - 83 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 36 IS - 1 N2 - The safety and efficacy of dirithromycin and clarithromycin were compared in a single-blind, multicentre study of patients with acute bacterial exacerbation of chronic bronchitis (AECB). Patients received either dirithromycin, 500 mg once daily for 5 days, or clarithromycin, 250 mg twice daily for 7 days. A total of 212 patients entered the study, of whom 191 qualified for efficacy analysis. Favourable post-therapy clinical and bacteriological response rates for qualified patients (95 dirithromycin and 96 clarithromycin) were similar: 89.5% and 68.8% for dirithromycin vs 94.8% and 71.9% for clarithromycin. At late post-therapy evaluation, favourable clinical and bacteriological response rates were achieved in 98.8% and 96.2% of dirithromycin patients and 95.3% and 93.3% of clarithromycin patients, respectively. These differences were neither statistically nor clinically significantly different. Both drugs had similar efficacy against Haemophilus influenzae and both were well tolerated. Dirithromycin, administered as a single daily dose for just 5 days resulted in complete compliance in all but four patients. In clarithromycin-treated patients, requiring a 7-day course of twice-daily treatment, compliance was less satisfactory, with 12 patients failing to comply, though the between-group difference was not statistically significant. It can be concluded that 5 days of dirithromycin, 500 mg once daily is as safe and effective as 7 days of clarithromycin, 250 mg, twice daily in the treatment of AECB. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/8537264/A_comparison_of_5_days_of_dirithromycin_and_7_days_of_clarithromycin_in_acute_bacterial_exacerbation_of_chronic_bronchitis_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/36.1.173 DB - PRIME DP - Unbound Medicine ER -