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Antibody-secreting cells and their relation to humoral antibodies in serum and in nasopharyngeal aspirates in children with pneumococcal acute otitis media.
J Infect Dis. 1996 Jan; 173(1):136-41.JI

Abstract

Mucosal and systemic antibody responses to pneumococcal capsular polysaccharide were studied in 17 children with culture-verified pneumococcal acute otitis media. Serotype-specific antibody-secreting cells (ASCs) in peripheral blood and antibodies in acute and convalescent sera and nasopharyngeal aspirates were measured. A polysaccharide-specific ASC response was induced in all subjects. The response was age dependent, and the dominant antibody class was IgA. Three children > 24 months old had > 100 IgA-class ASCs/10(6) cells and serum and nasopharyngeal IgA responses; 2 had only a nasopharyngeal IgA response. None of 8 children < 24 months old showed a systemic response; however, a nasopharyngeal IgA response was detected in 1. Results suggest that whole pneumococci can induce a mucosal polysaccharide-specific antibody response independent of the systemic response. Results are also in accordance with earlier studies suggesting that the mucosal immune system matures earlier in life than does the systemic immune response.

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Authors+Show Affiliations

Nieminen T
National Public Health Institute, University of Helsinki, Finland.
Virolainen A
No affiliation info available
Käyhty H
No affiliation info available
Jero J
No affiliation info available
Karma P
No affiliation info available
Leinonen M
No affiliation info available
Eskola J
No affiliation info available

MeSH

Acute DiseaseAntibodies, BacterialAntibody-Producing CellsBacterial CapsulesChild, PreschoolEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulinsInfantMaleNasal Lavage FluidNasopharynxOtitis Media, SuppurativePneumococcal InfectionsPolysaccharides, BacterialSerotypingStreptococcus pneumoniae

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8537650

Citation

Nieminen, T, et al. "Antibody-secreting Cells and Their Relation to Humoral Antibodies in Serum and in Nasopharyngeal Aspirates in Children With Pneumococcal Acute Otitis Media." The Journal of Infectious Diseases, vol. 173, no. 1, 1996, pp. 136-41.
Nieminen T, Virolainen A, Käyhty H, et al. Antibody-secreting cells and their relation to humoral antibodies in serum and in nasopharyngeal aspirates in children with pneumococcal acute otitis media. J Infect Dis. 1996;173(1):136-41.
Nieminen, T., Virolainen, A., Käyhty, H., Jero, J., Karma, P., Leinonen, M., & Eskola, J. (1996). Antibody-secreting cells and their relation to humoral antibodies in serum and in nasopharyngeal aspirates in children with pneumococcal acute otitis media. The Journal of Infectious Diseases, 173(1), 136-41.
Nieminen T, et al. Antibody-secreting Cells and Their Relation to Humoral Antibodies in Serum and in Nasopharyngeal Aspirates in Children With Pneumococcal Acute Otitis Media. J Infect Dis. 1996;173(1):136-41. PubMed PMID: 8537650.
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TY - JOUR T1 - Antibody-secreting cells and their relation to humoral antibodies in serum and in nasopharyngeal aspirates in children with pneumococcal acute otitis media. AU - Nieminen,T, AU - Virolainen,A, AU - Käyhty,H, AU - Jero,J, AU - Karma,P, AU - Leinonen,M, AU - Eskola,J, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 136 EP - 41 JF - The Journal of infectious diseases JO - J Infect Dis VL - 173 IS - 1 N2 - Mucosal and systemic antibody responses to pneumococcal capsular polysaccharide were studied in 17 children with culture-verified pneumococcal acute otitis media. Serotype-specific antibody-secreting cells (ASCs) in peripheral blood and antibodies in acute and convalescent sera and nasopharyngeal aspirates were measured. A polysaccharide-specific ASC response was induced in all subjects. The response was age dependent, and the dominant antibody class was IgA. Three children > 24 months old had > 100 IgA-class ASCs/10(6) cells and serum and nasopharyngeal IgA responses; 2 had only a nasopharyngeal IgA response. None of 8 children < 24 months old showed a systemic response; however, a nasopharyngeal IgA response was detected in 1. Results suggest that whole pneumococci can induce a mucosal polysaccharide-specific antibody response independent of the systemic response. Results are also in accordance with earlier studies suggesting that the mucosal immune system matures earlier in life than does the systemic immune response. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/8537650/Antibody_secreting_cells_and_their_relation_to_humoral_antibodies_in_serum_and_in_nasopharyngeal_aspirates_in_children_with_pneumococcal_acute_otitis_media_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/173.1.136 DB - PRIME DP - Unbound Medicine ER -