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Cohort studies of fat intake and the risk of breast cancer--a pooled analysis.
N Engl J Med 1996; 334(6):356-61NEJM

Abstract

BACKGROUND

Experiments in animals, international correlation comparisons, and case-control studies support an association between dietary fat intake and the incidence of breast cancer. Most cohort studies do not corroborate the association, but they have been criticized for involving small numbers of cases, homogeneous fat intake, and measurement errors in estimates of fat intake.

METHODS

We identified seven prospective studies in four countries that met specific criteria and analyzed the primary data in a standardized manner. Pooled estimates of the relation of fat intake to the risk of breast cancer were calculated, and data from study-specific validation studies were used to adjust the results for measurement error.

RESULTS

Information about 4980 cases from studies including 337,819 women was available. When women in the highest quintile of energy-adjusted total fat intake were compared with women in the lowest quintile, the multivariate pooled relative risk of breast cancer was 1.05 (95 percent confidence interval, 0.94 to 1.16). Relative risks for saturated, monounsaturated, and polyunsaturated fat and for cholesterol, considered individually, were also close to unity. There was little overall association between the percentage of energy intake from fat and the risk of breast cancer, even among women whose energy intake from fat was less than 20 percent. Correcting for error in the measurement of nutrient intake did not materially alter these findings.

CONCLUSIONS

We found no evidence of a positive association between total dietary fat intake and the risk of breast cancer. There was no reduction in risk even among women whose energy intake from fat was less than 20 percent of total energy intake. In the context of the Western lifestyle, lowering the total intake of fat in midlife is unlikely to reduce the risk of breast cancer substantially.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8538706

Citation

Hunter, D J., et al. "Cohort Studies of Fat Intake and the Risk of Breast Cancer--a Pooled Analysis." The New England Journal of Medicine, vol. 334, no. 6, 1996, pp. 356-61.
Hunter DJ, Spiegelman D, Adami HO, et al. Cohort studies of fat intake and the risk of breast cancer--a pooled analysis. N Engl J Med. 1996;334(6):356-61.
Hunter, D. J., Spiegelman, D., Adami, H. O., Beeson, L., van den Brandt, P. A., Folsom, A. R., ... Howe, G. R. (1996). Cohort studies of fat intake and the risk of breast cancer--a pooled analysis. The New England Journal of Medicine, 334(6), pp. 356-61.
Hunter DJ, et al. Cohort Studies of Fat Intake and the Risk of Breast Cancer--a Pooled Analysis. N Engl J Med. 1996 Feb 8;334(6):356-61. PubMed PMID: 8538706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cohort studies of fat intake and the risk of breast cancer--a pooled analysis. A1 - Hunter,D J, AU - Spiegelman,D, AU - Adami,H O, AU - Beeson,L, AU - van den Brandt,P A, AU - Folsom,A R, AU - Fraser,G E, AU - Goldbohm,R A, AU - Graham,S, AU - Howe,G R, PY - 1996/2/8/pubmed PY - 1996/2/8/medline PY - 1996/2/8/entrez SP - 356 EP - 61 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 334 IS - 6 N2 - BACKGROUND: Experiments in animals, international correlation comparisons, and case-control studies support an association between dietary fat intake and the incidence of breast cancer. Most cohort studies do not corroborate the association, but they have been criticized for involving small numbers of cases, homogeneous fat intake, and measurement errors in estimates of fat intake. METHODS: We identified seven prospective studies in four countries that met specific criteria and analyzed the primary data in a standardized manner. Pooled estimates of the relation of fat intake to the risk of breast cancer were calculated, and data from study-specific validation studies were used to adjust the results for measurement error. RESULTS: Information about 4980 cases from studies including 337,819 women was available. When women in the highest quintile of energy-adjusted total fat intake were compared with women in the lowest quintile, the multivariate pooled relative risk of breast cancer was 1.05 (95 percent confidence interval, 0.94 to 1.16). Relative risks for saturated, monounsaturated, and polyunsaturated fat and for cholesterol, considered individually, were also close to unity. There was little overall association between the percentage of energy intake from fat and the risk of breast cancer, even among women whose energy intake from fat was less than 20 percent. Correcting for error in the measurement of nutrient intake did not materially alter these findings. CONCLUSIONS: We found no evidence of a positive association between total dietary fat intake and the risk of breast cancer. There was no reduction in risk even among women whose energy intake from fat was less than 20 percent of total energy intake. In the context of the Western lifestyle, lowering the total intake of fat in midlife is unlikely to reduce the risk of breast cancer substantially. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/8538706/Cohort_studies_of_fat_intake_and_the_risk_of_breast_cancer__a_pooled_analysis_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM199602083340603?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -