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Clinical evaluation of an optimized 1.1% amino-acid solution for peritoneal dialysis.
Nephrol Dial Transplant. 1995; 10(8):1432-7.ND

Abstract

A significant percentage of dialysed patients have inadequate protein intake. One strategy for treating the protein malnutrition in peritoneal dialysis patients is to replace glucose in the dialysis solution by amino acids. A new peritoneal dialysis solution containing 1.1% amino acids in a formulation optimized for renal patients and with a lactate concentration of 40 mmol/l has been evaluated. Fifteen CAPD patients completed a non-randomized prospective 3-month study. Each patient received 2 litres of the optimised 1.1% amino acid solution for the second exchange of the day with a dwell time of 5-6 h. Indicators of efficacy were serum albumin and transferrin. After 3 months of intraperitoneal amino acids, serum albumin levels significantly increased from 32.7 +/- 2.3 to 35.1 +/- 2.2 g/l (mean +/- SD; P < 0.01). This occurred in parallel with a significant increase in transferrin levels from 2.21 +/- 0.26 to 2.39 +/- 0.27 g/l (P < 0.05). As expected, urea rose from 23.7 +/- 6.8 to 29.9 +/- 9.4 mmol/l. Interestingly bicarbonate did not change (25.5 +/- 4.2 versus 25.2 +/- 3.3 mmol/l). These results suggest that the optimized formulation is effective in improving nutritional parameters in CAPD patients while avoiding unwanted side-effects such as acidosis.

Authors+Show Affiliations

Hôpital Louis Pasteur, Colmar, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8538938

Citation

Faller, B, et al. "Clinical Evaluation of an Optimized 1.1% Amino-acid Solution for Peritoneal Dialysis." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 10, no. 8, 1995, pp. 1432-7.
Faller B, Aparicio M, Faict D, et al. Clinical evaluation of an optimized 1.1% amino-acid solution for peritoneal dialysis. Nephrol Dial Transplant. 1995;10(8):1432-7.
Faller, B., Aparicio, M., Faict, D., De Vos, C., de Précigout, V., Larroumet, N., Guiberteau, R., Jones, M., & Peluso, F. (1995). Clinical evaluation of an optimized 1.1% amino-acid solution for peritoneal dialysis. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 10(8), 1432-7.
Faller B, et al. Clinical Evaluation of an Optimized 1.1% Amino-acid Solution for Peritoneal Dialysis. Nephrol Dial Transplant. 1995;10(8):1432-7. PubMed PMID: 8538938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical evaluation of an optimized 1.1% amino-acid solution for peritoneal dialysis. AU - Faller,B, AU - Aparicio,M, AU - Faict,D, AU - De Vos,C, AU - de Précigout,V, AU - Larroumet,N, AU - Guiberteau,R, AU - Jones,M, AU - Peluso,F, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 1432 EP - 7 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol. Dial. Transplant. VL - 10 IS - 8 N2 - A significant percentage of dialysed patients have inadequate protein intake. One strategy for treating the protein malnutrition in peritoneal dialysis patients is to replace glucose in the dialysis solution by amino acids. A new peritoneal dialysis solution containing 1.1% amino acids in a formulation optimized for renal patients and with a lactate concentration of 40 mmol/l has been evaluated. Fifteen CAPD patients completed a non-randomized prospective 3-month study. Each patient received 2 litres of the optimised 1.1% amino acid solution for the second exchange of the day with a dwell time of 5-6 h. Indicators of efficacy were serum albumin and transferrin. After 3 months of intraperitoneal amino acids, serum albumin levels significantly increased from 32.7 +/- 2.3 to 35.1 +/- 2.2 g/l (mean +/- SD; P < 0.01). This occurred in parallel with a significant increase in transferrin levels from 2.21 +/- 0.26 to 2.39 +/- 0.27 g/l (P < 0.05). As expected, urea rose from 23.7 +/- 6.8 to 29.9 +/- 9.4 mmol/l. Interestingly bicarbonate did not change (25.5 +/- 4.2 versus 25.2 +/- 3.3 mmol/l). These results suggest that the optimized formulation is effective in improving nutritional parameters in CAPD patients while avoiding unwanted side-effects such as acidosis. SN - 0931-0509 UR - https://www.unboundmedicine.com/medline/citation/8538938/Clinical_evaluation_of_an_optimized_1_1_amino_acid_solution_for_peritoneal_dialysis_ L2 - https://medlineplus.gov/nutritionforolderadults.html DB - PRIME DP - Unbound Medicine ER -