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Metastatic gastrinomas: localization with selective arterial injection of secretin.
Radiology. 1996 Jan; 198(1):77-84.R

Abstract

PURPOSE

To evaluate localization of hepatic metastases with the intraarterial secretin injection test in Zollinger-Ellison syndrome (ZES).

MATERIALS AND METHODS

Results in 74 patients with ZES (aged 15-70 years) were retrospectively studied. All patients had undergone computed tomography (CT), magnetic resonance (MR) imaging, ultrasound, abdominal angiography, and an intraarterial secretin test, in which venous blood is sampled periodically after injection of secretin.

RESULTS

Twenty-two patients had liver metastases. An increase in venous gastrin concentration of at least 25% at 20 seconds or 50% at 30 seconds after injection indicated a positive result. Results were positive in 41% of patients with and 2% without liver metastases (P < .0001). Sensitivity of the intraarterial secretin test was 41%; of CT and ultrasound, 64%; and of MR imaging and angiography, 77%. Intraarterial secretin test results assisted in clinical management in 22% of patients.

CONCLUSION

With the criteria developed, the intraarterial secretin test had high specificity but low sensitivity. It should be used when imaging results are unclear.

Authors+Show Affiliations

Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-1804, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8539410

Citation

Gibril, F, et al. "Metastatic Gastrinomas: Localization With Selective Arterial Injection of Secretin." Radiology, vol. 198, no. 1, 1996, pp. 77-84.
Gibril F, Doppman JL, Chang R, et al. Metastatic gastrinomas: localization with selective arterial injection of secretin. Radiology. 1996;198(1):77-84.
Gibril, F., Doppman, J. L., Chang, R., Weber, H. C., Termanini, B., & Jensen, R. T. (1996). Metastatic gastrinomas: localization with selective arterial injection of secretin. Radiology, 198(1), 77-84.
Gibril F, et al. Metastatic Gastrinomas: Localization With Selective Arterial Injection of Secretin. Radiology. 1996;198(1):77-84. PubMed PMID: 8539410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metastatic gastrinomas: localization with selective arterial injection of secretin. AU - Gibril,F, AU - Doppman,J L, AU - Chang,R, AU - Weber,H C, AU - Termanini,B, AU - Jensen,R T, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 77 EP - 84 JF - Radiology JO - Radiology VL - 198 IS - 1 N2 - PURPOSE: To evaluate localization of hepatic metastases with the intraarterial secretin injection test in Zollinger-Ellison syndrome (ZES). MATERIALS AND METHODS: Results in 74 patients with ZES (aged 15-70 years) were retrospectively studied. All patients had undergone computed tomography (CT), magnetic resonance (MR) imaging, ultrasound, abdominal angiography, and an intraarterial secretin test, in which venous blood is sampled periodically after injection of secretin. RESULTS: Twenty-two patients had liver metastases. An increase in venous gastrin concentration of at least 25% at 20 seconds or 50% at 30 seconds after injection indicated a positive result. Results were positive in 41% of patients with and 2% without liver metastases (P < .0001). Sensitivity of the intraarterial secretin test was 41%; of CT and ultrasound, 64%; and of MR imaging and angiography, 77%. Intraarterial secretin test results assisted in clinical management in 22% of patients. CONCLUSION: With the criteria developed, the intraarterial secretin test had high specificity but low sensitivity. It should be used when imaging results are unclear. SN - 0033-8419 UR - https://www.unboundmedicine.com/medline/citation/8539410/Metastatic_gastrinomas:_localization_with_selective_arterial_injection_of_secretin_ L2 - https://pubs.rsna.org/doi/10.1148/radiology.198.1.8539410?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -