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[Investigations of the bioavailability of iron from bi- and trivalent iron salts (author's transl)].
Med Klin. 1977 Apr 15; 72(15):654-9.MK

Abstract

In a clinical pilot study, performed as an intraindividual comparison, 3 oral iron preparations, one bivalent iron sulfate (quick release stick capsule preparation) and two trivalent iron citrate complex preparations with different additives, were investigated on 9 healthy young male test persons by the iron absorption test (postabsorption serum iron concentration curves) in order to study the bioavailability of these drugs and their compatibility. Whereas both iron drugs proved equally compatible when administered in therapeutical doses, it was again confirmed that the enteral bioavailability of the ferrous iron sulfate is superior to that of the ferric iron complex preparation. According to these results the medication of ferric iron preparations seems once again to be proved unsuitable, trivalent iron having first to be reduced to bivalent absorbable iron, there however being usually not enough "reducing capacity" in the gastrointestinal tract to do this.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

853979

Citation

Dietzfelbinger, H, and W Kaboth. "[Investigations of the Bioavailability of Iron From Bi- and Trivalent Iron Salts (author's Transl)]." Medizinische Klinik, vol. 72, no. 15, 1977, pp. 654-9.
Dietzfelbinger H, Kaboth W. [Investigations of the bioavailability of iron from bi- and trivalent iron salts (author's transl)]. Med Klin. 1977;72(15):654-9.
Dietzfelbinger, H., & Kaboth, W. (1977). [Investigations of the bioavailability of iron from bi- and trivalent iron salts (author's transl)]. Medizinische Klinik, 72(15), 654-9.
Dietzfelbinger H, Kaboth W. [Investigations of the Bioavailability of Iron From Bi- and Trivalent Iron Salts (author's Transl)]. Med Klin. 1977 Apr 15;72(15):654-9. PubMed PMID: 853979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Investigations of the bioavailability of iron from bi- and trivalent iron salts (author's transl)]. AU - Dietzfelbinger,H, AU - Kaboth,W, PY - 1977/4/15/pubmed PY - 2000/3/22/medline PY - 1977/4/15/entrez SP - 654 EP - 9 JF - Medizinische Klinik JO - Med Klin VL - 72 IS - 15 N2 - In a clinical pilot study, performed as an intraindividual comparison, 3 oral iron preparations, one bivalent iron sulfate (quick release stick capsule preparation) and two trivalent iron citrate complex preparations with different additives, were investigated on 9 healthy young male test persons by the iron absorption test (postabsorption serum iron concentration curves) in order to study the bioavailability of these drugs and their compatibility. Whereas both iron drugs proved equally compatible when administered in therapeutical doses, it was again confirmed that the enteral bioavailability of the ferrous iron sulfate is superior to that of the ferric iron complex preparation. According to these results the medication of ferric iron preparations seems once again to be proved unsuitable, trivalent iron having first to be reduced to bivalent absorbable iron, there however being usually not enough "reducing capacity" in the gastrointestinal tract to do this. SN - 0025-8458 UR - https://www.unboundmedicine.com/medline/citation/853979/[Investigations_of_the_bioavailability_of_iron_from_bi__and_trivalent_iron_salts__author's_transl_]_ L2 - https://medlineplus.gov/iron.html DB - PRIME DP - Unbound Medicine ER -