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Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome.
Gynecol Endocrinol. 1995 Sep; 9(3):221-8.GE

Abstract

Hirsutism is a common symptom of women affected by polycystic ovary syndrome (PCOS). The effectiveness of the antiandrogen flutamide alone was studied in 25 patients affected by PCOS with severe hirsutism for a period of 24 months. Seventeen of these patients had not been treated before and eight had had previous but unsatisfactory therapy. Nineteen patients showed a normal body weight (BMI < 25 kg/m2) whereas six were obese (BMI > 35 kg/m2). A chemical and endocrinological evaluation and an assessment of the degree of hirsutism, assigned by Ferriman-Gallwey score (mean 22 +/- 3.038), was performed under baseline conditions. Patients started treatment with flutamide (Eulexin, Schering-Plough, Kenilworth, USA) at the dose of 500 mg daily. A chronobiological assessment of gonadotropin episodic secretion and of gonadotropin response to GnRH challenge (10 micrograms in bolus) was done before and on day 7 of flutamide administration. During treatment, our patients showed a marked and significant reduction of hirsutism starting from a score of 6 and reaching the maximum (9.6 + 2.1) at 24 months of therapy. No relevant hormonal changes or side-effects were observed during therapy. Our data demonstrate that hirsutism in PCOS can rapidly and markedly respond to treatment with flutamide alone without important side-effects even if administered for a long period.

Authors+Show Affiliations

Pucci E
Endocrinological Institute, University of Pisa, Italy.
Genazzani AD
No affiliation info available
Monzani F
No affiliation info available
Lippi F
No affiliation info available
Angelini F
No affiliation info available
Gargani M
No affiliation info available
Barletta D
No affiliation info available
Luisi M
No affiliation info available
Genazzani AR
No affiliation info available

MeSH

AdultAndrogen AntagonistsDehydroepiandrosteroneDehydroepiandrosterone SulfateFemaleFlutamideFollicle Stimulating HormoneGonadotropin-Releasing HormoneHirsutismHumansLuteinizing HormonePolycystic Ovary SyndromeUltrasonography

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8540292

Citation

Pucci, E, et al. "Prolonged Treatment of Hirsutism With Flutamide Alone in Patients Affected By Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 9, no. 3, 1995, pp. 221-8.
Pucci E, Genazzani AD, Monzani F, et al. Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome. Gynecol Endocrinol. 1995;9(3):221-8.
Pucci, E., Genazzani, A. D., Monzani, F., Lippi, F., Angelini, F., Gargani, M., Barletta, D., Luisi, M., & Genazzani, A. R. (1995). Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 9(3), 221-8.
Pucci E, et al. Prolonged Treatment of Hirsutism With Flutamide Alone in Patients Affected By Polycystic Ovary Syndrome. Gynecol Endocrinol. 1995;9(3):221-8. PubMed PMID: 8540292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolonged treatment of hirsutism with flutamide alone in patients affected by polycystic ovary syndrome. AU - Pucci,E, AU - Genazzani,A D, AU - Monzani,F, AU - Lippi,F, AU - Angelini,F, AU - Gargani,M, AU - Barletta,D, AU - Luisi,M, AU - Genazzani,A R, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 221 EP - 8 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 9 IS - 3 N2 - Hirsutism is a common symptom of women affected by polycystic ovary syndrome (PCOS). The effectiveness of the antiandrogen flutamide alone was studied in 25 patients affected by PCOS with severe hirsutism for a period of 24 months. Seventeen of these patients had not been treated before and eight had had previous but unsatisfactory therapy. Nineteen patients showed a normal body weight (BMI < 25 kg/m2) whereas six were obese (BMI > 35 kg/m2). A chemical and endocrinological evaluation and an assessment of the degree of hirsutism, assigned by Ferriman-Gallwey score (mean 22 +/- 3.038), was performed under baseline conditions. Patients started treatment with flutamide (Eulexin, Schering-Plough, Kenilworth, USA) at the dose of 500 mg daily. A chronobiological assessment of gonadotropin episodic secretion and of gonadotropin response to GnRH challenge (10 micrograms in bolus) was done before and on day 7 of flutamide administration. During treatment, our patients showed a marked and significant reduction of hirsutism starting from a score of 6 and reaching the maximum (9.6 + 2.1) at 24 months of therapy. No relevant hormonal changes or side-effects were observed during therapy. Our data demonstrate that hirsutism in PCOS can rapidly and markedly respond to treatment with flutamide alone without important side-effects even if administered for a long period. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/8540292/Prolonged_treatment_of_hirsutism_with_flutamide_alone_in_patients_affected_by_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -