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Schizophrenia after prenatal famine. Further evidence.

Abstract

BACKGROUND

Suggestive findings of an earlier study that prenatal nutritional deficiency was a determinant of schizophrenia prompted us to undertake a second test of the hypothesis using more precise data on both exposure and outcome.

METHODS

Among persons born in the cities of western Netherlands during 1944 through 1946, we compared the risk for schizophrenia in those exposed and unexposed during early gestation to the Dutch Hunger Winter of 1944/1945. The frequency of hospitalized patients with schizophrenia at age 24 to 48 years in the exposed and unexposed birth cohorts was ascertained from a national psychiatric registry.

RESULTS

The most exposed birth cohort, conceived at the height of the famine, showed a twofold and statistically significant increase in the risk for schizophrenia (relative risk [RR] = 2.0; 95% confidence interval [CI] = 1.2 to 3.4; P < .01) in both men (RR = 1.9; 95% CI = 1.0 to 3.7; P = .05) and women (RR = 2.2; 95% CI = 1.0 to 4.7; P = .04). Among all birth cohorts of 1944 through 1946, the risk for schizophrenia clearly peaked in this exposed cohort.

CONCLUSION

Prenatal nutritional deficiency may play a role in the origin of some cases of schizophrenia.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry, Columbia University, New York, NY, USA.

    , , , , ,

    Source

    Archives of general psychiatry 53:1 1996 Jan pg 25-31

    MeSH

    Adult
    Child
    Child, Preschool
    Cohort Studies
    Female
    Hospitalization
    Humans
    Incidence
    Infant
    Male
    Middle Aged
    Netherlands
    Neural Tube Defects
    Pregnancy
    Pregnancy Complications
    Prenatal Exposure Delayed Effects
    Registries
    Risk Factors
    Schizophrenia
    Starvation

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8540774

    Citation

    Susser, E, et al. "Schizophrenia After Prenatal Famine. Further Evidence." Archives of General Psychiatry, vol. 53, no. 1, 1996, pp. 25-31.
    Susser E, Neugebauer R, Hoek HW, et al. Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry. 1996;53(1):25-31.
    Susser, E., Neugebauer, R., Hoek, H. W., Brown, A. S., Lin, S., Labovitz, D., & Gorman, J. M. (1996). Schizophrenia after prenatal famine. Further evidence. Archives of General Psychiatry, 53(1), pp. 25-31.
    Susser E, et al. Schizophrenia After Prenatal Famine. Further Evidence. Arch Gen Psychiatry. 1996;53(1):25-31. PubMed PMID: 8540774.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Schizophrenia after prenatal famine. Further evidence. AU - Susser,E, AU - Neugebauer,R, AU - Hoek,H W, AU - Brown,A S, AU - Lin,S, AU - Labovitz,D, AU - Gorman,J M, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 25 EP - 31 JF - Archives of general psychiatry JO - Arch. Gen. Psychiatry VL - 53 IS - 1 N2 - BACKGROUND: Suggestive findings of an earlier study that prenatal nutritional deficiency was a determinant of schizophrenia prompted us to undertake a second test of the hypothesis using more precise data on both exposure and outcome. METHODS: Among persons born in the cities of western Netherlands during 1944 through 1946, we compared the risk for schizophrenia in those exposed and unexposed during early gestation to the Dutch Hunger Winter of 1944/1945. The frequency of hospitalized patients with schizophrenia at age 24 to 48 years in the exposed and unexposed birth cohorts was ascertained from a national psychiatric registry. RESULTS: The most exposed birth cohort, conceived at the height of the famine, showed a twofold and statistically significant increase in the risk for schizophrenia (relative risk [RR] = 2.0; 95% confidence interval [CI] = 1.2 to 3.4; P < .01) in both men (RR = 1.9; 95% CI = 1.0 to 3.7; P = .05) and women (RR = 2.2; 95% CI = 1.0 to 4.7; P = .04). Among all birth cohorts of 1944 through 1946, the risk for schizophrenia clearly peaked in this exposed cohort. CONCLUSION: Prenatal nutritional deficiency may play a role in the origin of some cases of schizophrenia. SN - 0003-990X UR - https://www.unboundmedicine.com/medline/citation/8540774/Schizophrenia_after_prenatal_famine__Further_evidence_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=8540774.ui DB - PRIME DP - Unbound Medicine ER -