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[The protective efficacy of BCG against leprosy in São Paulo, Brazil].
Bol Oficina Sanit Panam 1995; 119(5):415-21BO

Abstract

The protection against leprosy conferred by BCG vaccination was evaluated in a case-control study. Selected for the study were 97 patients under 16 years of age who had been diagnosed with leprosy (cases) and 385 healthy persons (controls), who were matched according to sex, age, place of residence, and type of contact (intra- or extradomicilliary). The cases were selected from a register of active cases as well as a series of new leprosy patients treated in 50 centers in the city of São Paulo, Brasil. To estimate the protective effect of BCG, the prevalences of BCG scars among cases and controls were compared. The presence of one or more scars was associated with a protective efficacy of 90% (95% confidence interval: 78%-96%). Stratified analysis by age group, sex, socioeconomic level, and clinical form of leprosy did not reveal any important differences in the protection conferred by the vaccine. The significance of these findings and the appropriateness of using BCG in leprosy control programs is discussed.

Authors+Show Affiliations

Organización Panamericana de la Salud, Setor de Embaixadas Norte, Brasília, D.F., Brasil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

8540997

Citation

Lombardi, C, et al. "[The Protective Efficacy of BCG Against Leprosy in São Paulo, Brazil]." Boletin De La Oficina Sanitaria Panamericana. Pan American Sanitary Bureau, vol. 119, no. 5, 1995, pp. 415-21.
Lombardi C, Pedrazzani ES, Pedrazzani JC, et al. [The protective efficacy of BCG against leprosy in São Paulo, Brazil]. Bol Oficina Sanit Panam. 1995;119(5):415-21.
Lombardi, C., Pedrazzani, E. S., Pedrazzani, J. C., Ferreira Filho, P., & Zicker, F. (1995). [The protective efficacy of BCG against leprosy in São Paulo, Brazil]. Boletin De La Oficina Sanitaria Panamericana. Pan American Sanitary Bureau, 119(5), pp. 415-21.
Lombardi C, et al. [The Protective Efficacy of BCG Against Leprosy in São Paulo, Brazil]. Bol Oficina Sanit Panam. 1995;119(5):415-21. PubMed PMID: 8540997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The protective efficacy of BCG against leprosy in São Paulo, Brazil]. AU - Lombardi,C, AU - Pedrazzani,E S, AU - Pedrazzani,J C, AU - Ferreira Filho,P, AU - Zicker,F, PY - 1995/11/1/pubmed PY - 1995/11/1/medline PY - 1995/11/1/entrez SP - 415 EP - 21 JF - Boletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau JO - Bol Oficina Sanit Panam VL - 119 IS - 5 N2 - The protection against leprosy conferred by BCG vaccination was evaluated in a case-control study. Selected for the study were 97 patients under 16 years of age who had been diagnosed with leprosy (cases) and 385 healthy persons (controls), who were matched according to sex, age, place of residence, and type of contact (intra- or extradomicilliary). The cases were selected from a register of active cases as well as a series of new leprosy patients treated in 50 centers in the city of São Paulo, Brasil. To estimate the protective effect of BCG, the prevalences of BCG scars among cases and controls were compared. The presence of one or more scars was associated with a protective efficacy of 90% (95% confidence interval: 78%-96%). Stratified analysis by age group, sex, socioeconomic level, and clinical form of leprosy did not reveal any important differences in the protection conferred by the vaccine. The significance of these findings and the appropriateness of using BCG in leprosy control programs is discussed. SN - 0030-0632 UR - https://www.unboundmedicine.com/medline/citation/8540997/[The_protective_efficacy_of_BCG_against_leprosy_in_São_Paulo_Brazil]_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -