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Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid.
Br J Nutr 1995; 74(5):701-15BJ

Abstract

The effects of oral administration of linoleic- and gamma-linolenic-acid-rich oils on the clinical and histopathological manifestations of experimental autoimmune encephalomyelitis (EAE) were investigated in Lewis rats 7 d post-inoculation. gamma-Linolenic-acid-rich fungal (Mucor javanicus) oil at 500 mg/kg body weight abrogated clinical and histological signs of EAE although at doses of 200 and 1000 mg/kg body weight it was only effective in delaying the onset of clinical disease. Linoleic-acid-rich safflower-seed (Carthamus tinctorius) oil at 500, 750 and 1000 mg/kg body weight decreased the severity of clinical EAE disease in a dose-dependent manner. The effects in healthy animals of orally administered gamma-linolenic-acid-rich fungal oil (500 mg/kg body weight) and linoleic-acid-rich safflower-seed oil (1000 mg/kg body weight) on splenic lymphocyte proliferative responses to the T-cell mitogen concanavalin-A (Con A), membrane fatty acid composition and lymphocyte sub-sets were also studied. Both treatments enhanced the T-cell proliferative response to Con A. There was no significant effect on the proportion of splenic CD8+ or CD4+ lymphocytes. Compositional studies on splenic phosphoglyceride fatty acids of oil-treated animals suggest the above responses were associated with increases in spleen dihomo-gamma-linolenic and arachidonic acids.

Authors+Show Affiliations

Immunology Department, United Medical School, Guy's Hosptial, London.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8541276

Citation

Harbige, L S., et al. "Prevention of Experimental Autoimmune Encephalomyelitis in Lewis Rats By a Novel Fungal Source of Gamma-linolenic Acid." The British Journal of Nutrition, vol. 74, no. 5, 1995, pp. 701-15.
Harbige LS, Yeatman N, Amor S, et al. Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid. Br J Nutr. 1995;74(5):701-15.
Harbige, L. S., Yeatman, N., Amor, S., & Crawford, M. A. (1995). Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid. The British Journal of Nutrition, 74(5), pp. 701-15.
Harbige LS, et al. Prevention of Experimental Autoimmune Encephalomyelitis in Lewis Rats By a Novel Fungal Source of Gamma-linolenic Acid. Br J Nutr. 1995;74(5):701-15. PubMed PMID: 8541276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of experimental autoimmune encephalomyelitis in Lewis rats by a novel fungal source of gamma-linolenic acid. AU - Harbige,L S, AU - Yeatman,N, AU - Amor,S, AU - Crawford,M A, PY - 1995/11/1/pubmed PY - 1995/11/1/medline PY - 1995/11/1/entrez SP - 701 EP - 15 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 74 IS - 5 N2 - The effects of oral administration of linoleic- and gamma-linolenic-acid-rich oils on the clinical and histopathological manifestations of experimental autoimmune encephalomyelitis (EAE) were investigated in Lewis rats 7 d post-inoculation. gamma-Linolenic-acid-rich fungal (Mucor javanicus) oil at 500 mg/kg body weight abrogated clinical and histological signs of EAE although at doses of 200 and 1000 mg/kg body weight it was only effective in delaying the onset of clinical disease. Linoleic-acid-rich safflower-seed (Carthamus tinctorius) oil at 500, 750 and 1000 mg/kg body weight decreased the severity of clinical EAE disease in a dose-dependent manner. The effects in healthy animals of orally administered gamma-linolenic-acid-rich fungal oil (500 mg/kg body weight) and linoleic-acid-rich safflower-seed oil (1000 mg/kg body weight) on splenic lymphocyte proliferative responses to the T-cell mitogen concanavalin-A (Con A), membrane fatty acid composition and lymphocyte sub-sets were also studied. Both treatments enhanced the T-cell proliferative response to Con A. There was no significant effect on the proportion of splenic CD8+ or CD4+ lymphocytes. Compositional studies on splenic phosphoglyceride fatty acids of oil-treated animals suggest the above responses were associated with increases in spleen dihomo-gamma-linolenic and arachidonic acids. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/8541276/Prevention_of_experimental_autoimmune_encephalomyelitis_in_Lewis_rats_by_a_novel_fungal_source_of_gamma_linolenic_acid_ L2 - https://www.cambridge.org/core/product/identifier/S0007114595001747/type/journal_article DB - PRIME DP - Unbound Medicine ER -