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Myeloid lineage involvement in acute lymphoblastic leukemia: a morphology antibody chromosomes (MAC) study.
Exp Hematol. 1995 Dec; 23(14):1563-7.EH

Abstract

We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22+ and CD3+ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10+ and CD19+ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts.

Authors+Show Affiliations

Department of Medical Genetics, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8542947

Citation

Larramendy, M, et al. "Myeloid Lineage Involvement in Acute Lymphoblastic Leukemia: a Morphology Antibody Chromosomes (MAC) Study." Experimental Hematology, vol. 23, no. 14, 1995, pp. 1563-7.
Larramendy M, el-Rifai W, Saarinen U, et al. Myeloid lineage involvement in acute lymphoblastic leukemia: a morphology antibody chromosomes (MAC) study. Exp Hematol. 1995;23(14):1563-7.
Larramendy, M., el-Rifai, W., Saarinen, U., Alitalo, R., Luomahaara, S., & Knuutila, S. (1995). Myeloid lineage involvement in acute lymphoblastic leukemia: a morphology antibody chromosomes (MAC) study. Experimental Hematology, 23(14), 1563-7.
Larramendy M, et al. Myeloid Lineage Involvement in Acute Lymphoblastic Leukemia: a Morphology Antibody Chromosomes (MAC) Study. Exp Hematol. 1995;23(14):1563-7. PubMed PMID: 8542947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myeloid lineage involvement in acute lymphoblastic leukemia: a morphology antibody chromosomes (MAC) study. AU - Larramendy,M, AU - el-Rifai,W, AU - Saarinen,U, AU - Alitalo,R, AU - Luomahaara,S, AU - Knuutila,S, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 1563 EP - 7 JF - Experimental hematology JO - Exp Hematol VL - 23 IS - 14 N2 - We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22+ and CD3+ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10+ and CD19+ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts. SN - 0301-472X UR - https://www.unboundmedicine.com/medline/citation/8542947/Myeloid_lineage_involvement_in_acute_lymphoblastic_leukemia:_a_morphology_antibody_chromosomes__MAC__study_ L2 - http://www.diseaseinfosearch.org/result/188 DB - PRIME DP - Unbound Medicine ER -