Tags

Type your tag names separated by a space and hit enter

Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride.
J Neurol Sci. 1995 Oct; 132(2):156-61.JN

Abstract

Striatal dopamine D2 receptors were studied, using positron emission tomography (PET), in 10 patients with early Parkinson's disease without any antiparkinsonian medication and in 14 healthy controls. [11C]Raclopride was used as ligand and an equilibrium method was applied. The maximum count of receptors (Bmax) and their dissociation constant (Kd) were calculated according to the Scatchard principle. In parkinsonian patients, the Bmax of D2 receptors was increased in the putamen contralateral to the predominant symptoms, as compared to the opposite putamen, by 33% (p = 0.0008). In the caudate nucleus no significant side to side differences was noted. On comparison with age-matched healthy controls, Bmax values in the putamen (p = 0.0012) but not in the caudate nucleus contralateral to the side of predominant clinical symptoms were increased in PD patients. The Kd values were unchanged. The difference in putaminal Bmax values between the opposite hemispheres correlated with the difference in the severity of parkinsonian motor symptoms between the two body sides (r = 0.69, p = 0.03). The present results show that there is both a relative and absolute increase in the number of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease.

Authors+Show Affiliations

Department of Neurology, University of Turku, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8543941

Citation

Rinne, J O., et al. "Increased Density of Dopamine D2 Receptors in the Putamen, but Not in the Caudate Nucleus in Early Parkinson's Disease: a PET Study With [11C]raclopride." Journal of the Neurological Sciences, vol. 132, no. 2, 1995, pp. 156-61.
Rinne JO, Laihinen A, Ruottinen H, et al. Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride. J Neurol Sci. 1995;132(2):156-61.
Rinne, J. O., Laihinen, A., Ruottinen, H., Ruotsalainen, U., Någren, K., Lehikoinen, P., Oikonen, V., & Rinne, U. K. (1995). Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride. Journal of the Neurological Sciences, 132(2), 156-61.
Rinne JO, et al. Increased Density of Dopamine D2 Receptors in the Putamen, but Not in the Caudate Nucleus in Early Parkinson's Disease: a PET Study With [11C]raclopride. J Neurol Sci. 1995;132(2):156-61. PubMed PMID: 8543941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased density of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease: a PET study with [11C]raclopride. AU - Rinne,J O, AU - Laihinen,A, AU - Ruottinen,H, AU - Ruotsalainen,U, AU - Någren,K, AU - Lehikoinen,P, AU - Oikonen,V, AU - Rinne,U K, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 156 EP - 61 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 132 IS - 2 N2 - Striatal dopamine D2 receptors were studied, using positron emission tomography (PET), in 10 patients with early Parkinson's disease without any antiparkinsonian medication and in 14 healthy controls. [11C]Raclopride was used as ligand and an equilibrium method was applied. The maximum count of receptors (Bmax) and their dissociation constant (Kd) were calculated according to the Scatchard principle. In parkinsonian patients, the Bmax of D2 receptors was increased in the putamen contralateral to the predominant symptoms, as compared to the opposite putamen, by 33% (p = 0.0008). In the caudate nucleus no significant side to side differences was noted. On comparison with age-matched healthy controls, Bmax values in the putamen (p = 0.0012) but not in the caudate nucleus contralateral to the side of predominant clinical symptoms were increased in PD patients. The Kd values were unchanged. The difference in putaminal Bmax values between the opposite hemispheres correlated with the difference in the severity of parkinsonian motor symptoms between the two body sides (r = 0.69, p = 0.03). The present results show that there is both a relative and absolute increase in the number of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/8543941/Increased_density_of_dopamine_D2_receptors_in_the_putamen_but_not_in_the_caudate_nucleus_in_early_Parkinson's_disease:_a_PET_study_with_[11C]raclopride_ DB - PRIME DP - Unbound Medicine ER -