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In vivo study of artemisinin and its derivatives against primary amebic meningoencephalitis caused by Naegleria fowleri.
J Parasitol. 1995 Dec; 81(6):1012-3.JP

Abstract

Artemisinin and its derivatives, beta-arteether and sodium artesunic acid, have been evaluated for activity against experimental primary amebic meningoencephalitis and the efficacy of these compounds has been compared with that of the standard drug amphotericin B. In vivo experiments in Swiss mice have shown that amphotericin B at a dose of 2.5 mg/kg for 5 days produced 100% protection in the mice infected intranasally with Naegleria fowleri. Artemisinin, beta-arteether, and sodium artesunic acid, even when tested at high doses (60-180 mg/kg x 5 days), were not curative and showed only slight protection as indicated by extension of mean survival time.

Authors+Show Affiliations

Central Drug Research Institute, Lucknow, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8544041

Citation

Gupta, S, et al. "In Vivo Study of Artemisinin and Its Derivatives Against Primary Amebic Meningoencephalitis Caused By Naegleria Fowleri." The Journal of Parasitology, vol. 81, no. 6, 1995, pp. 1012-3.
Gupta S, Ghosh PK, Dutta GP, et al. In vivo study of artemisinin and its derivatives against primary amebic meningoencephalitis caused by Naegleria fowleri. J Parasitol. 1995;81(6):1012-3.
Gupta, S., Ghosh, P. K., Dutta, G. P., & Vishwakarma, R. A. (1995). In vivo study of artemisinin and its derivatives against primary amebic meningoencephalitis caused by Naegleria fowleri. The Journal of Parasitology, 81(6), 1012-3.
Gupta S, et al. In Vivo Study of Artemisinin and Its Derivatives Against Primary Amebic Meningoencephalitis Caused By Naegleria Fowleri. J Parasitol. 1995;81(6):1012-3. PubMed PMID: 8544041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo study of artemisinin and its derivatives against primary amebic meningoencephalitis caused by Naegleria fowleri. AU - Gupta,S, AU - Ghosh,P K, AU - Dutta,G P, AU - Vishwakarma,R A, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 1012 EP - 3 JF - The Journal of parasitology JO - J. Parasitol. VL - 81 IS - 6 N2 - Artemisinin and its derivatives, beta-arteether and sodium artesunic acid, have been evaluated for activity against experimental primary amebic meningoencephalitis and the efficacy of these compounds has been compared with that of the standard drug amphotericin B. In vivo experiments in Swiss mice have shown that amphotericin B at a dose of 2.5 mg/kg for 5 days produced 100% protection in the mice infected intranasally with Naegleria fowleri. Artemisinin, beta-arteether, and sodium artesunic acid, even when tested at high doses (60-180 mg/kg x 5 days), were not curative and showed only slight protection as indicated by extension of mean survival time. SN - 0022-3395 UR - https://www.unboundmedicine.com/medline/citation/8544041/In_vivo_study_of_artemisinin_and_its_derivatives_against_primary_amebic_meningoencephalitis_caused_by_Naegleria_fowleri_ DB - PRIME DP - Unbound Medicine ER -