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Diurnal variation in glomerular charge selectivity, urinary albumin excretion and blood pressure in insulin-dependent diabetic patients.
Kidney Int. 1995 Nov; 48(5):1559-62.KI

Abstract

The urinary albumin excretion rate (AER) in a subgroup of patients with insulin-dependent diabetes mellitus (IDDM) steadily increases. In these patients a concomitant reduction of the glomerular charge selectivity index (SI) has been demonstrated. The aim of the present study was to evaluate whether diurnal variation in AER could be related to a diurnal variation in SI and/or a diurnal blood pressure variation. Thirty-three patients with IDDM, 27 with normal albumin excretion (AER < 20 micrograms/min; group D(o)) and six with incipient nephropathy (AER from 20 to 200 micrograms/min; group DA), were studied. AER and SI (renal clearance ratio of total-IgG/IgG4) were measured in three different urine collecting periods: period A (8:00 a.m. to 12:00 a.m.), period B (12:00 a.m. to bedtime) and period C (bedtime to 8:00 a.m.). A significant increase in SI was seen during the nighttime: period A, 1.6 (0.2 to 3.8; mean, range); period B, 1.7 (0.3 to 3.0); and period C, 2.0 (0.2 to 4.0); P = 0.01. Corresponding to this observation, an overall significant decrease in AER was found: period A, 10 (3 to 137) micrograms/min (median, range); period B, 8 (3 to 84) micrograms/min; and period C, 5 (0 to 78) micrograms/min; P < 0.001. In all three sampling periods a negative correlation was found between AER and SI. When group D(o) was analyzed alone, the results were similar. Diurnal variation in blood pressure was significantly positively correlated with AER in group DA, but was not correlated to variation in AER in D(o). We suggest that in normoalbuminuric IDDM patients diurnal variation in AER is related to diurnal variation in SI.

Authors+Show Affiliations

Steno Diabetes Center, Gentofte, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8544414

Citation

Hansen, P M., et al. "Diurnal Variation in Glomerular Charge Selectivity, Urinary Albumin Excretion and Blood Pressure in Insulin-dependent Diabetic Patients." Kidney International, vol. 48, no. 5, 1995, pp. 1559-62.
Hansen PM, Goddijn PP, Kofoed-Enevoldsen A, et al. Diurnal variation in glomerular charge selectivity, urinary albumin excretion and blood pressure in insulin-dependent diabetic patients. Kidney Int. 1995;48(5):1559-62.
Hansen, P. M., Goddijn, P. P., Kofoed-Enevoldsen, A., van Tol, K. M., Bilo, H. J., & Deckert, T. (1995). Diurnal variation in glomerular charge selectivity, urinary albumin excretion and blood pressure in insulin-dependent diabetic patients. Kidney International, 48(5), 1559-62.
Hansen PM, et al. Diurnal Variation in Glomerular Charge Selectivity, Urinary Albumin Excretion and Blood Pressure in Insulin-dependent Diabetic Patients. Kidney Int. 1995;48(5):1559-62. PubMed PMID: 8544414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diurnal variation in glomerular charge selectivity, urinary albumin excretion and blood pressure in insulin-dependent diabetic patients. AU - Hansen,P M, AU - Goddijn,P P, AU - Kofoed-Enevoldsen,A, AU - van Tol,K M, AU - Bilo,H J, AU - Deckert,T, PY - 1995/11/1/pubmed PY - 1995/11/1/medline PY - 1995/11/1/entrez SP - 1559 EP - 62 JF - Kidney international JO - Kidney Int VL - 48 IS - 5 N2 - The urinary albumin excretion rate (AER) in a subgroup of patients with insulin-dependent diabetes mellitus (IDDM) steadily increases. In these patients a concomitant reduction of the glomerular charge selectivity index (SI) has been demonstrated. The aim of the present study was to evaluate whether diurnal variation in AER could be related to a diurnal variation in SI and/or a diurnal blood pressure variation. Thirty-three patients with IDDM, 27 with normal albumin excretion (AER < 20 micrograms/min; group D(o)) and six with incipient nephropathy (AER from 20 to 200 micrograms/min; group DA), were studied. AER and SI (renal clearance ratio of total-IgG/IgG4) were measured in three different urine collecting periods: period A (8:00 a.m. to 12:00 a.m.), period B (12:00 a.m. to bedtime) and period C (bedtime to 8:00 a.m.). A significant increase in SI was seen during the nighttime: period A, 1.6 (0.2 to 3.8; mean, range); period B, 1.7 (0.3 to 3.0); and period C, 2.0 (0.2 to 4.0); P = 0.01. Corresponding to this observation, an overall significant decrease in AER was found: period A, 10 (3 to 137) micrograms/min (median, range); period B, 8 (3 to 84) micrograms/min; and period C, 5 (0 to 78) micrograms/min; P < 0.001. In all three sampling periods a negative correlation was found between AER and SI. When group D(o) was analyzed alone, the results were similar. Diurnal variation in blood pressure was significantly positively correlated with AER in group DA, but was not correlated to variation in AER in D(o). We suggest that in normoalbuminuric IDDM patients diurnal variation in AER is related to diurnal variation in SI. SN - 0085-2538 UR - https://www.unboundmedicine.com/medline/citation/8544414/Diurnal_variation_in_glomerular_charge_selectivity_urinary_albumin_excretion_and_blood_pressure_in_insulin_dependent_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)59219-3 DB - PRIME DP - Unbound Medicine ER -