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[Lactose digestion by milk fermented with Lactobacillus acidophilus and Lactobacillus casei of human origin].
Medicina (B Aires). 1995; 55(3):237-42.M

Abstract

The aim of the present study was to determine whether a fermented milk containing Lactobacillus casei and Lactobacillus acidophilus strains isolated from human subjects (CFM) and developed by CERELA (Centro de referencia para Lactobacilos) is better tolerated than regular milk (RM) by subjects with lactase deficiency (< 1 unidad) and lactose intolerance. We studied the digestion of the lactose present in the two milk preparations which were administered to 18 healthy subjects with lactase deficiency and 12 control subjects. Each subject ingested in random sequence on different days, 480 ml CFM, 480 ml RM and 240 ml CFM and 240 ml RM. Breath hydrogen (H2) test was used to measure lactose absorption and orocecal transit time (OCTT). The peak H2 ppm results after 480 ml of CFM were ingested, reached 19.5 +/- 12.1 ppm. The same reading when 480 ml of RM were ingested was 52.6 +/- 31.9 ppm (p < 0.008). The results also showed that 480 ml of CFM delayed OCTT median 111.0 +/- 6.78 min versus 54.0 +/- 5.09 min of RM (p < 0.001) and reduced the development of symptoms (p < 0.08) such as bloating (p < 0.05), borborygmi (p < 0.025) diarrhea (p < 0.05) and abdominal colics (p < 0.05). In spite of the small number of cases studied, it seems justified to conclude that CERELA fermented milk significantly influences lactose digestion and minor development of symptoms in lactase-deficient subjects and lengthens significantly the orocecal transit time compared with regular milk.

Authors+Show Affiliations

Cátedra de Salud Pública, Facultad de Medicina, Universidad de Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

8544722

Citation

Gaón, D, et al. "[Lactose Digestion By Milk Fermented With Lactobacillus Acidophilus and Lactobacillus Casei of Human Origin]." Medicina, vol. 55, no. 3, 1995, pp. 237-42.
Gaón D, Doweck Y, Gómez Zavaglia A, et al. [Lactose digestion by milk fermented with Lactobacillus acidophilus and Lactobacillus casei of human origin]. Medicina (B Aires). 1995;55(3):237-42.
Gaón, D., Doweck, Y., Gómez Zavaglia, A., Ruiz Holgado, A., & Oliver, G. (1995). [Lactose digestion by milk fermented with Lactobacillus acidophilus and Lactobacillus casei of human origin]. Medicina, 55(3), 237-42.
Gaón D, et al. [Lactose Digestion By Milk Fermented With Lactobacillus Acidophilus and Lactobacillus Casei of Human Origin]. Medicina (B Aires). 1995;55(3):237-42. PubMed PMID: 8544722.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Lactose digestion by milk fermented with Lactobacillus acidophilus and Lactobacillus casei of human origin]. AU - Gaón,D, AU - Doweck,Y, AU - Gómez Zavaglia,A, AU - Ruiz Holgado,A, AU - Oliver,G, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 237 EP - 42 JF - Medicina JO - Medicina (B Aires) VL - 55 IS - 3 N2 - The aim of the present study was to determine whether a fermented milk containing Lactobacillus casei and Lactobacillus acidophilus strains isolated from human subjects (CFM) and developed by CERELA (Centro de referencia para Lactobacilos) is better tolerated than regular milk (RM) by subjects with lactase deficiency (< 1 unidad) and lactose intolerance. We studied the digestion of the lactose present in the two milk preparations which were administered to 18 healthy subjects with lactase deficiency and 12 control subjects. Each subject ingested in random sequence on different days, 480 ml CFM, 480 ml RM and 240 ml CFM and 240 ml RM. Breath hydrogen (H2) test was used to measure lactose absorption and orocecal transit time (OCTT). The peak H2 ppm results after 480 ml of CFM were ingested, reached 19.5 +/- 12.1 ppm. The same reading when 480 ml of RM were ingested was 52.6 +/- 31.9 ppm (p < 0.008). The results also showed that 480 ml of CFM delayed OCTT median 111.0 +/- 6.78 min versus 54.0 +/- 5.09 min of RM (p < 0.001) and reduced the development of symptoms (p < 0.08) such as bloating (p < 0.05), borborygmi (p < 0.025) diarrhea (p < 0.05) and abdominal colics (p < 0.05). In spite of the small number of cases studied, it seems justified to conclude that CERELA fermented milk significantly influences lactose digestion and minor development of symptoms in lactase-deficient subjects and lengthens significantly the orocecal transit time compared with regular milk. SN - 0025-7680 UR - https://www.unboundmedicine.com/medline/citation/8544722/[Lactose_digestion_by_milk_fermented_with_Lactobacillus_acidophilus_and_Lactobacillus_casei_of_human_origin]_ L2 - https://medlineplus.gov/lactoseintolerance.html DB - PRIME DP - Unbound Medicine ER -