Tags

Type your tag names separated by a space and hit enter

Elimination of fox rabies from Belgium using a recombinant vaccinia-rabies vaccine: an update.
Vet Microbiol. 1995 Sep; 46(1-3):269-79.VM

Abstract

To improve both safety and stability of the vaccines used in the field to vaccinate foxes against rabies by the oral route, a recombinant vaccinia virus, expressing the glycoprotein of rabies virus (VVTGgRAB) has been developed. VVTGgRAB innocuity was verified in target species and in domestic animals as well as in numerous wild animal species that could compete with the red fox in consuming vaccine baits in Europe. Oral immunization of foxes, by distributing VVTGgRAB vaccine-baits, was undertaken in the whole of the infected area of Belgium (10,000 km2). Five campaigns of fox vaccination covering the whole infected area were carried out from the autumn of 1989 until 1991. Each time, 150,000 vaccine-baits were dispersed by air at a mean density of 15 per km2. These campaigns induced a drastic decrease in the incidence of rabies and the elimination of the disease from 80% of the initial infected area. Regarding the geographical evolution of rabies in Belgium and in adjacent regions in neighbouring countries, new spatial strategies for bait dispersal were planned for 1992, 1993 and 1994: successive restricted campaigns were carried out along political borders only. These campaigns induced a new decrease of incidence; no rabid foxes could be detected in 1993 in spite of an improved epidemiological surveillance. In 1994, rabies was confirmed again in 13 foxes collected in a region situated close to the French border. These cases demonstrate the persistence of a focus of rabies on the border and justify further restricted campaigns of vaccination.

Authors+Show Affiliations

Department of Immunology-Vaccinology, Faculty of Veterinary Medicine, University of Liege, Belgium.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8545965

Citation

Brochier, B, et al. "Elimination of Fox Rabies From Belgium Using a Recombinant Vaccinia-rabies Vaccine: an Update." Veterinary Microbiology, vol. 46, no. 1-3, 1995, pp. 269-79.
Brochier B, Costy F, Pastoret PP. Elimination of fox rabies from Belgium using a recombinant vaccinia-rabies vaccine: an update. Vet Microbiol. 1995;46(1-3):269-79.
Brochier, B., Costy, F., & Pastoret, P. P. (1995). Elimination of fox rabies from Belgium using a recombinant vaccinia-rabies vaccine: an update. Veterinary Microbiology, 46(1-3), 269-79.
Brochier B, Costy F, Pastoret PP. Elimination of Fox Rabies From Belgium Using a Recombinant Vaccinia-rabies Vaccine: an Update. Vet Microbiol. 1995;46(1-3):269-79. PubMed PMID: 8545965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elimination of fox rabies from Belgium using a recombinant vaccinia-rabies vaccine: an update. AU - Brochier,B, AU - Costy,F, AU - Pastoret,P P, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 269 EP - 79 JF - Veterinary microbiology JO - Vet Microbiol VL - 46 IS - 1-3 N2 - To improve both safety and stability of the vaccines used in the field to vaccinate foxes against rabies by the oral route, a recombinant vaccinia virus, expressing the glycoprotein of rabies virus (VVTGgRAB) has been developed. VVTGgRAB innocuity was verified in target species and in domestic animals as well as in numerous wild animal species that could compete with the red fox in consuming vaccine baits in Europe. Oral immunization of foxes, by distributing VVTGgRAB vaccine-baits, was undertaken in the whole of the infected area of Belgium (10,000 km2). Five campaigns of fox vaccination covering the whole infected area were carried out from the autumn of 1989 until 1991. Each time, 150,000 vaccine-baits were dispersed by air at a mean density of 15 per km2. These campaigns induced a drastic decrease in the incidence of rabies and the elimination of the disease from 80% of the initial infected area. Regarding the geographical evolution of rabies in Belgium and in adjacent regions in neighbouring countries, new spatial strategies for bait dispersal were planned for 1992, 1993 and 1994: successive restricted campaigns were carried out along political borders only. These campaigns induced a new decrease of incidence; no rabid foxes could be detected in 1993 in spite of an improved epidemiological surveillance. In 1994, rabies was confirmed again in 13 foxes collected in a region situated close to the French border. These cases demonstrate the persistence of a focus of rabies on the border and justify further restricted campaigns of vaccination. SN - 0378-1135 UR - https://www.unboundmedicine.com/medline/citation/8545965/Elimination_of_fox_rabies_from_Belgium_using_a_recombinant_vaccinia_rabies_vaccine:_an_update_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-1135(95)00091-N DB - PRIME DP - Unbound Medicine ER -