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Genetic evidence that the Lewy body variant is indeed a phenotypic variant of Alzheimer's disease.
Brain Cogn. 1995 Aug; 28(3):259-65.BC

Abstract

Lewy Body Variant (LBV) patients present as Alzheimer's disease (AD) clinically; about two-thirds also have mild extrapyramidal features. At autopsy, neocortical and brain stem Lewy bodies are present in addition to changes diagnostic of AD. We have found that the Apolipoprotein E4 allele is a major genetic risk factor for LBV as it is for "pure AD," in contrast to subjects with diffuse Lewy body disease or Parkinson's disease. This genetic evidence supports the concept that LBV--the second most common neurodegenerative form of dementia--is a phenotypic variant of AD.

Authors+Show Affiliations

Department of Neurosciences, University of California, San Diego, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

8546853

Citation

Katzman, R, et al. "Genetic Evidence That the Lewy Body Variant Is Indeed a Phenotypic Variant of Alzheimer's Disease." Brain and Cognition, vol. 28, no. 3, 1995, pp. 259-65.
Katzman R, Galasko D, Saitoh T, et al. Genetic evidence that the Lewy body variant is indeed a phenotypic variant of Alzheimer's disease. Brain Cogn. 1995;28(3):259-65.
Katzman, R., Galasko, D., Saitoh, T., Thal, L. J., & Hansen, L. (1995). Genetic evidence that the Lewy body variant is indeed a phenotypic variant of Alzheimer's disease. Brain and Cognition, 28(3), 259-65.
Katzman R, et al. Genetic Evidence That the Lewy Body Variant Is Indeed a Phenotypic Variant of Alzheimer's Disease. Brain Cogn. 1995;28(3):259-65. PubMed PMID: 8546853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic evidence that the Lewy body variant is indeed a phenotypic variant of Alzheimer's disease. AU - Katzman,R, AU - Galasko,D, AU - Saitoh,T, AU - Thal,L J, AU - Hansen,L, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 259 EP - 65 JF - Brain and cognition JO - Brain Cogn VL - 28 IS - 3 N2 - Lewy Body Variant (LBV) patients present as Alzheimer's disease (AD) clinically; about two-thirds also have mild extrapyramidal features. At autopsy, neocortical and brain stem Lewy bodies are present in addition to changes diagnostic of AD. We have found that the Apolipoprotein E4 allele is a major genetic risk factor for LBV as it is for "pure AD," in contrast to subjects with diffuse Lewy body disease or Parkinson's disease. This genetic evidence supports the concept that LBV--the second most common neurodegenerative form of dementia--is a phenotypic variant of AD. SN - 0278-2626 UR - https://www.unboundmedicine.com/medline/citation/8546853/Genetic_evidence_that_the_Lewy_body_variant_is_indeed_a_phenotypic_variant_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-2626(85)71256-0 DB - PRIME DP - Unbound Medicine ER -