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Lewy body diseases with dementia: pathophysiology and treatment.
Brain Cogn. 1995 Aug; 28(3):266-80.BC

Abstract

There are four major Lewy body disorders with dementia: Parkinson's disease (PD), PD with Alzheimer's disease (AD), cortical Lewy bodies and neuritic plaques, and cortical Lewy bodies and no concomitant AD-type pathology. A variety of pathogenetic processes may underly this panoply of diseases including oxidative stress, excitatory amino acid toxicity, amyloidogenesis, neurofibrillary tangle formation, inflammation, apoptotic cell death, and neurotransmitter deficiency. Treatment strategies include transmitter replacement, neuroprotection, agents to limit AD-type pathology, iron chelation, and anti-inflammatory drugs. Patients with Lewy body disorders exhibit cognitive decline resulting from a variety of disease processes and treatment must address the disease-specific pathogenesis.

Authors+Show Affiliations

Department of Neurology, UCLA School of Medicine 90024, USA.

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

8546854

Citation

Cummings, J L.. "Lewy Body Diseases With Dementia: Pathophysiology and Treatment." Brain and Cognition, vol. 28, no. 3, 1995, pp. 266-80.
Cummings JL. Lewy body diseases with dementia: pathophysiology and treatment. Brain Cogn. 1995;28(3):266-80.
Cummings, J. L. (1995). Lewy body diseases with dementia: pathophysiology and treatment. Brain and Cognition, 28(3), 266-80.
Cummings JL. Lewy Body Diseases With Dementia: Pathophysiology and Treatment. Brain Cogn. 1995;28(3):266-80. PubMed PMID: 8546854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lewy body diseases with dementia: pathophysiology and treatment. A1 - Cummings,J L, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 266 EP - 80 JF - Brain and cognition JO - Brain Cogn VL - 28 IS - 3 N2 - There are four major Lewy body disorders with dementia: Parkinson's disease (PD), PD with Alzheimer's disease (AD), cortical Lewy bodies and neuritic plaques, and cortical Lewy bodies and no concomitant AD-type pathology. A variety of pathogenetic processes may underly this panoply of diseases including oxidative stress, excitatory amino acid toxicity, amyloidogenesis, neurofibrillary tangle formation, inflammation, apoptotic cell death, and neurotransmitter deficiency. Treatment strategies include transmitter replacement, neuroprotection, agents to limit AD-type pathology, iron chelation, and anti-inflammatory drugs. Patients with Lewy body disorders exhibit cognitive decline resulting from a variety of disease processes and treatment must address the disease-specific pathogenesis. SN - 0278-2626 UR - https://www.unboundmedicine.com/medline/citation/8546854/Lewy_body_diseases_with_dementia:_pathophysiology_and_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-2626(85)71257-2 DB - PRIME DP - Unbound Medicine ER -