Tags

Type your tag names separated by a space and hit enter

Resistance to activated protein C in healthy women taking oral contraceptives.
Br J Haematol. 1995 Oct; 91(2):465-70.BJ

Abstract

Resistance to activated protein C (APC) is at present considered the most frequent laboratory abnormality in patients with deep-vein thrombosis. An increased risk for venous thrombosis is associated to the use of oral contraceptives (OC). We studied APC sensitivity in 50 healthy women taking OC and in 50 healthy controls, matched for age, smoking habit, educational and social levels, and the main biochemical routinary parameters. Subjects with a personal or familial history of thrombosis and also with chronic or acute diseases were excluded. Protein C, protein S, antithrombin III and lupus anticoagulant activity (LAC) were also evaluated. Increased fibrinogen and protein C levels, decreased protein S. and shortened PT and APTT were also observed in women taking OC. APC sensitivity ratio (APC-SR) was significantly lower in the OC group than in a control group (2.6 +/- 0.38 v 2.81 +/- 0.35, P < 0.01). Seven of eight women with APC ratio < or = 2 (APC resistant) were OC users: the difference of prevalence was statistically significant (chi-squared test, P < 0.05). Only two out of eight women were found heterozygous for the Leiden factor V mutation. Two APC-resistant women without the Leiden mutation subsequently discontinued OC and both then normalized their APC-SR. We conclude that acquired factors, i.e. oral contraceptives, may play an important role in determining plasma APC resistance.

Authors+Show Affiliations

Institute of Medical Pathology, University of Verona, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8547095

Citation

Olivieri, O, et al. "Resistance to Activated Protein C in Healthy Women Taking Oral Contraceptives." British Journal of Haematology, vol. 91, no. 2, 1995, pp. 465-70.
Olivieri O, Friso S, Manzato F, et al. Resistance to activated protein C in healthy women taking oral contraceptives. Br J Haematol. 1995;91(2):465-70.
Olivieri, O., Friso, S., Manzato, F., Guella, A., Bernardi, F., Lunghi, B., Girelli, D., Azzini, M., Brocco, G., & Russo, C. (1995). Resistance to activated protein C in healthy women taking oral contraceptives. British Journal of Haematology, 91(2), 465-70.
Olivieri O, et al. Resistance to Activated Protein C in Healthy Women Taking Oral Contraceptives. Br J Haematol. 1995;91(2):465-70. PubMed PMID: 8547095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resistance to activated protein C in healthy women taking oral contraceptives. A1 - Olivieri,O, AU - Friso,S, AU - Manzato,F, AU - Guella,A, AU - Bernardi,F, AU - Lunghi,B, AU - Girelli,D, AU - Azzini,M, AU - Brocco,G, AU - Russo,C, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez KW - Biology KW - Case Control Studies KW - Contraception KW - Contraceptive Methods KW - Developed Countries KW - Diseases KW - Embolism KW - Europe KW - Family Planning KW - Genetics KW - Italy KW - Measurement KW - Mediterranean Countries KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Low-dose KW - Prevalence KW - Research Methodology KW - Research Report KW - Southern Europe KW - Studies KW - Thromboembolism KW - Thrombosis KW - Vascular Diseases SP - 465 EP - 70 JF - British journal of haematology JO - Br J Haematol VL - 91 IS - 2 N2 - Resistance to activated protein C (APC) is at present considered the most frequent laboratory abnormality in patients with deep-vein thrombosis. An increased risk for venous thrombosis is associated to the use of oral contraceptives (OC). We studied APC sensitivity in 50 healthy women taking OC and in 50 healthy controls, matched for age, smoking habit, educational and social levels, and the main biochemical routinary parameters. Subjects with a personal or familial history of thrombosis and also with chronic or acute diseases were excluded. Protein C, protein S, antithrombin III and lupus anticoagulant activity (LAC) were also evaluated. Increased fibrinogen and protein C levels, decreased protein S. and shortened PT and APTT were also observed in women taking OC. APC sensitivity ratio (APC-SR) was significantly lower in the OC group than in a control group (2.6 +/- 0.38 v 2.81 +/- 0.35, P < 0.01). Seven of eight women with APC ratio < or = 2 (APC resistant) were OC users: the difference of prevalence was statistically significant (chi-squared test, P < 0.05). Only two out of eight women were found heterozygous for the Leiden factor V mutation. Two APC-resistant women without the Leiden mutation subsequently discontinued OC and both then normalized their APC-SR. We conclude that acquired factors, i.e. oral contraceptives, may play an important role in determining plasma APC resistance. SN - 0007-1048 UR - https://www.unboundmedicine.com/medline/citation/8547095/Resistance_to_activated_protein_C_in_healthy_women_taking_oral_contraceptives_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0007-1048&amp;date=1995&amp;volume=91&amp;issue=2&amp;spage=465 DB - PRIME DP - Unbound Medicine ER -