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Clinical experience with acarbose: results of a Canadian multicentre study.
Clin Invest Med. 1995 Aug; 18(4):318-24.CI

Abstract

Current therapeutic options for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) focus on regimens that primarily lower fasting blood glucose concentrations. In several short-term studies, the alpha-glucosidase inhibitor, acarbose, has been reported to significantly lower post-prandial plasma glucose levels as well as HbA1c. The primary objective of this present study was to assess the long-term efficacy of adjunctive acarbose therapy to improve metabolic control. Over a 1-y period, acarbose or placebo was administered to 4 groups of patients: those managed by diet only, diet and sulfonylurea, diet and biguanide, and diet and insulin. In all treatment groups, the addition of acarbose resulted in significant reductions in postprandial blood glucose levels. Additionally, HbA1C was significantly lower after 12 months of acarbose therapy, compared with placebo, in all groups except the diet and insulin group. The addition of acarbose consequently expands the armamentarium available to clinicians for the optimization of glycemic control in patients with NIDDM.

Authors+Show Affiliations

Centre de recherche, Hôtel-Dieu de Montréal, Quebec.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

8549019

Citation

Rodger, N W., et al. "Clinical Experience With Acarbose: Results of a Canadian Multicentre Study." Clinical and Investigative Medicine. Medecine Clinique Et Experimentale, vol. 18, no. 4, 1995, pp. 318-24.
Rodger NW, Chiasson JL, Josse RG, et al. Clinical experience with acarbose: results of a Canadian multicentre study. Clin Invest Med. 1995;18(4):318-24.
Rodger, N. W., Chiasson, J. L., Josse, R. G., Hunt, J. A., Palmason, C., Ross, S. A., Ryan, E. A., Tan, M. H., & Wolever, T. M. (1995). Clinical experience with acarbose: results of a Canadian multicentre study. Clinical and Investigative Medicine. Medecine Clinique Et Experimentale, 18(4), 318-24.
Rodger NW, et al. Clinical Experience With Acarbose: Results of a Canadian Multicentre Study. Clin Invest Med. 1995;18(4):318-24. PubMed PMID: 8549019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical experience with acarbose: results of a Canadian multicentre study. AU - Rodger,N W, AU - Chiasson,J L, AU - Josse,R G, AU - Hunt,J A, AU - Palmason,C, AU - Ross,S A, AU - Ryan,E A, AU - Tan,M H, AU - Wolever,T M, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 318 EP - 24 JF - Clinical and investigative medicine. Medecine clinique et experimentale JO - Clin Invest Med VL - 18 IS - 4 N2 - Current therapeutic options for the treatment of non-insulin-dependent diabetes mellitus (NIDDM) focus on regimens that primarily lower fasting blood glucose concentrations. In several short-term studies, the alpha-glucosidase inhibitor, acarbose, has been reported to significantly lower post-prandial plasma glucose levels as well as HbA1c. The primary objective of this present study was to assess the long-term efficacy of adjunctive acarbose therapy to improve metabolic control. Over a 1-y period, acarbose or placebo was administered to 4 groups of patients: those managed by diet only, diet and sulfonylurea, diet and biguanide, and diet and insulin. In all treatment groups, the addition of acarbose resulted in significant reductions in postprandial blood glucose levels. Additionally, HbA1C was significantly lower after 12 months of acarbose therapy, compared with placebo, in all groups except the diet and insulin group. The addition of acarbose consequently expands the armamentarium available to clinicians for the optimization of glycemic control in patients with NIDDM. SN - 0147-958X UR - https://www.unboundmedicine.com/medline/citation/8549019/Clinical_experience_with_acarbose:_results_of_a_Canadian_multicentre_study_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -