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Effect of acute haemodilution on right atrial type-B receptor activity in anaesthetized cats.
Indian J Physiol Pharmacol. 1995 Jul; 39(3):216-22.IJ

Abstract

In order to investigate whether the sensitivity of atrial type-B receptors to its natural stimulus is altered during acute haemodilution, experiments were conducted in nine anaesthetized, artificially ventilated and thoracotomized cats. Haemodilution was achieved by replacement of blood by the same volume of dextran (MW 150000). Atrial receptor activity, arterial blood pressure, right atrial pressure and ECG were recorded. Heart rate was calculated from ECG records. Arterial blood hematocrit was measured. Mean arterial blood pressure and heart rate were not altered by haemodilution even at a hematocrit level of 12.17 +/- 0.93 percent. Average activity of type-B atrial receptors, mean right atrial pressure, right atrial peak 'v' pressure, right atrial initial 'v' pressure and right atrial 'v' wave amplitude were changed significantly (r < 0.05) during acute haemodilution when the hematocrit was 12.17 +/- 0.93 percent but the atrial type-B receptor activity per cycle did not show any significant change. Average activity of type-B receptors increased from 8.56 +/- 1.02 spikes/sec to 9.56 +/- 1.11 spikes/sec. Mean right atrial pressure, right atrial 'v' wave amplitude, right atrial peak 'v' pressure increased significantly (P < 0.05) from respective control values. Right atrial initial 'v' wave pressure decreased significantly. Heart rate changed from 168.11 +/- 5.42 beats/min to 170.89 +/- 5.65 beats/min. Mean arterial pressure changed from 134.33 +/- 0.89 mmHg to 135.67 +/- 1.46 mmHg.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8550113

Citation

Bhunia, S, et al. "Effect of Acute Haemodilution On Right Atrial type-B Receptor Activity in Anaesthetized Cats." Indian Journal of Physiology and Pharmacology, vol. 39, no. 3, 1995, pp. 216-22.
Bhunia S, Bhattacharya N, Fahim M. Effect of acute haemodilution on right atrial type-B receptor activity in anaesthetized cats. Indian J Physiol Pharmacol. 1995;39(3):216-22.
Bhunia, S., Bhattacharya, N., & Fahim, M. (1995). Effect of acute haemodilution on right atrial type-B receptor activity in anaesthetized cats. Indian Journal of Physiology and Pharmacology, 39(3), 216-22.
Bhunia S, Bhattacharya N, Fahim M. Effect of Acute Haemodilution On Right Atrial type-B Receptor Activity in Anaesthetized Cats. Indian J Physiol Pharmacol. 1995;39(3):216-22. PubMed PMID: 8550113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of acute haemodilution on right atrial type-B receptor activity in anaesthetized cats. AU - Bhunia,S, AU - Bhattacharya,N, AU - Fahim,M, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 216 EP - 22 JF - Indian journal of physiology and pharmacology JO - Indian J. Physiol. Pharmacol. VL - 39 IS - 3 N2 - In order to investigate whether the sensitivity of atrial type-B receptors to its natural stimulus is altered during acute haemodilution, experiments were conducted in nine anaesthetized, artificially ventilated and thoracotomized cats. Haemodilution was achieved by replacement of blood by the same volume of dextran (MW 150000). Atrial receptor activity, arterial blood pressure, right atrial pressure and ECG were recorded. Heart rate was calculated from ECG records. Arterial blood hematocrit was measured. Mean arterial blood pressure and heart rate were not altered by haemodilution even at a hematocrit level of 12.17 +/- 0.93 percent. Average activity of type-B atrial receptors, mean right atrial pressure, right atrial peak 'v' pressure, right atrial initial 'v' pressure and right atrial 'v' wave amplitude were changed significantly (r < 0.05) during acute haemodilution when the hematocrit was 12.17 +/- 0.93 percent but the atrial type-B receptor activity per cycle did not show any significant change. Average activity of type-B receptors increased from 8.56 +/- 1.02 spikes/sec to 9.56 +/- 1.11 spikes/sec. Mean right atrial pressure, right atrial 'v' wave amplitude, right atrial peak 'v' pressure increased significantly (P < 0.05) from respective control values. Right atrial initial 'v' wave pressure decreased significantly. Heart rate changed from 168.11 +/- 5.42 beats/min to 170.89 +/- 5.65 beats/min. Mean arterial pressure changed from 134.33 +/- 0.89 mmHg to 135.67 +/- 1.46 mmHg.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0019-5499 UR - https://www.unboundmedicine.com/medline/citation/8550113/Effect_of_acute_haemodilution_on_right_atrial_type_B_receptor_activity_in_anaesthetized_cats_ DB - PRIME DP - Unbound Medicine ER -