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The effect of oral coenzyme Q10 on the exercise tolerance of middle-aged, untrained men.
Int J Sports Med. 1995 Oct; 16(7):421-7.IJ

Abstract

In order to determine the effect of oral Coenzyme Q10 (CoQ10) dosing on exercise capacity, 15 middle-aged men (44.7 +/- 2.0 years) received either CoQ10 (150 mg/day x 2 months-Q10 GRP) or placebo (2 months-CON GRP). Blood CoQ10 levels increased (p < 0.05) during the treatment in the Q10 GRP (Pre = 0.72 +/- 0.06, 2 months = 1.08 +/- 0.14 micrograms/ml) and were unchanged in the CON GRP (Pre = 0.91 +/- 0.05, 2 month = 0.69 +/- 0.05 microgram/ml). Similarly, the subjective perception of vigor (visual analog scale 1-10 where, 10 = very energetic, and 0 = very, very unenergetic) increased (p < 0.05) in the Q10 GRP (Pre = 5.73 +/- 0.35, 2 month = 6.64 +/- 0.45). However, maximal oxygen consumption (VO2max Pre = 2.97 +/- 0.18, 2 month = 3.05 +/- 0.15 l/min) and lactate threshold (LT Pre = 2.04 +/- 0.12, 2 month = 2.08 +/- 0.12 l/min), as measured on the cycle ergometer, were unchanged as a result of the CoQ10 treatment, Neither forearm oxygen uptake, nor forearm blood flow was found to be affected by the CoQ10. Although lactate release during hand-grip testing tended to decrease in the Q10 GRP (Pre = 227 +/- 49, 2 month = 168.3 +/- 40 mumole/min) this was not significant (p > 0.05). It can be concluded that short-term (2 months) oral dosing with CoQ10 increases circulating blood levels of CoQ10 and the subjective perceived level of vigor in middle-aged men. However, short-term dosing does not improve aerobic capacity or firearm exercise metabolism as measured in this investigation.

Authors+Show Affiliations

Wright State University, Department of Orthopedics, Dayton, OH 45509, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8550248

Citation

Porter, D A., et al. "The Effect of Oral Coenzyme Q10 On the Exercise Tolerance of Middle-aged, Untrained Men." International Journal of Sports Medicine, vol. 16, no. 7, 1995, pp. 421-7.
Porter DA, Costill DL, Zachwieja JJ, et al. The effect of oral coenzyme Q10 on the exercise tolerance of middle-aged, untrained men. Int J Sports Med. 1995;16(7):421-7.
Porter, D. A., Costill, D. L., Zachwieja, J. J., Krzeminski, K., Fink, W. J., Wagner, E., & Folkers, K. (1995). The effect of oral coenzyme Q10 on the exercise tolerance of middle-aged, untrained men. International Journal of Sports Medicine, 16(7), 421-7.
Porter DA, et al. The Effect of Oral Coenzyme Q10 On the Exercise Tolerance of Middle-aged, Untrained Men. Int J Sports Med. 1995;16(7):421-7. PubMed PMID: 8550248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of oral coenzyme Q10 on the exercise tolerance of middle-aged, untrained men. AU - Porter,D A, AU - Costill,D L, AU - Zachwieja,J J, AU - Krzeminski,K, AU - Fink,W J, AU - Wagner,E, AU - Folkers,K, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 421 EP - 7 JF - International journal of sports medicine JO - Int J Sports Med VL - 16 IS - 7 N2 - In order to determine the effect of oral Coenzyme Q10 (CoQ10) dosing on exercise capacity, 15 middle-aged men (44.7 +/- 2.0 years) received either CoQ10 (150 mg/day x 2 months-Q10 GRP) or placebo (2 months-CON GRP). Blood CoQ10 levels increased (p < 0.05) during the treatment in the Q10 GRP (Pre = 0.72 +/- 0.06, 2 months = 1.08 +/- 0.14 micrograms/ml) and were unchanged in the CON GRP (Pre = 0.91 +/- 0.05, 2 month = 0.69 +/- 0.05 microgram/ml). Similarly, the subjective perception of vigor (visual analog scale 1-10 where, 10 = very energetic, and 0 = very, very unenergetic) increased (p < 0.05) in the Q10 GRP (Pre = 5.73 +/- 0.35, 2 month = 6.64 +/- 0.45). However, maximal oxygen consumption (VO2max Pre = 2.97 +/- 0.18, 2 month = 3.05 +/- 0.15 l/min) and lactate threshold (LT Pre = 2.04 +/- 0.12, 2 month = 2.08 +/- 0.12 l/min), as measured on the cycle ergometer, were unchanged as a result of the CoQ10 treatment, Neither forearm oxygen uptake, nor forearm blood flow was found to be affected by the CoQ10. Although lactate release during hand-grip testing tended to decrease in the Q10 GRP (Pre = 227 +/- 49, 2 month = 168.3 +/- 40 mumole/min) this was not significant (p > 0.05). It can be concluded that short-term (2 months) oral dosing with CoQ10 increases circulating blood levels of CoQ10 and the subjective perceived level of vigor in middle-aged men. However, short-term dosing does not improve aerobic capacity or firearm exercise metabolism as measured in this investigation. SN - 0172-4622 UR - https://www.unboundmedicine.com/medline/citation/8550248/The_effect_of_oral_coenzyme_Q10_on_the_exercise_tolerance_of_middle_aged_untrained_men_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-973031 DB - PRIME DP - Unbound Medicine ER -