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Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele.
J Clin Invest 1996; 97(1):65-72JCI

Abstract

The postprandial responses of apo B48, B100, E and lipids in triglyceride-rich lipoproteins (TRL) to a meal containing one-third of daily energy (39% fat calories) were compared in normolipidemic young men with apo E3/3 and apo E4/3 phenotypes. After the two groups consumed a diet rich in polyunsaturated fat for 15-29 d, their postabsorptive concentrations of TRL triglycerides, apo B48, and apo B100 were virtually identical, but their postprandial responses differed. In both groups, TRL apo B48 increased at 3 h but returned to postabsorptive values at 6 h only in the apo E3/3 group; in the apo E4/3 group the concentration of apo B48 at 6 h was 80% higher than postabsorptive values. TRL apo B100 also increased at 3 h in the two groups and fell to post-absorptive values at 6 h in the apo E3/3 group but remained 51% higher than postabsorptive concentrations in the apo E4/3 group; this response was closely coupled to that of TRL cholesterol and apo E. These observations suggest that clearance of intestinal and hepatogenous TRL remnants is impaired in young men with an apo E4/3 phenotype.

Authors+Show Affiliations

Cardiovascular Research Institute, University of California, San Francisco 94143-0130, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8550852

Citation

Bergeron, N, and R J. Havel. "Prolonged Postprandial Responses of Lipids and Apolipoproteins in Triglyceride-rich Lipoproteins of Individuals Expressing an Apolipoprotein Epsilon 4 Allele." The Journal of Clinical Investigation, vol. 97, no. 1, 1996, pp. 65-72.
Bergeron N, Havel RJ. Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele. J Clin Invest. 1996;97(1):65-72.
Bergeron, N., & Havel, R. J. (1996). Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele. The Journal of Clinical Investigation, 97(1), pp. 65-72.
Bergeron N, Havel RJ. Prolonged Postprandial Responses of Lipids and Apolipoproteins in Triglyceride-rich Lipoproteins of Individuals Expressing an Apolipoprotein Epsilon 4 Allele. J Clin Invest. 1996 Jan 1;97(1):65-72. PubMed PMID: 8550852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele. AU - Bergeron,N, AU - Havel,R J, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 65 EP - 72 JF - The Journal of clinical investigation JO - J. Clin. Invest. VL - 97 IS - 1 N2 - The postprandial responses of apo B48, B100, E and lipids in triglyceride-rich lipoproteins (TRL) to a meal containing one-third of daily energy (39% fat calories) were compared in normolipidemic young men with apo E3/3 and apo E4/3 phenotypes. After the two groups consumed a diet rich in polyunsaturated fat for 15-29 d, their postabsorptive concentrations of TRL triglycerides, apo B48, and apo B100 were virtually identical, but their postprandial responses differed. In both groups, TRL apo B48 increased at 3 h but returned to postabsorptive values at 6 h only in the apo E3/3 group; in the apo E4/3 group the concentration of apo B48 at 6 h was 80% higher than postabsorptive values. TRL apo B100 also increased at 3 h in the two groups and fell to post-absorptive values at 6 h in the apo E3/3 group but remained 51% higher than postabsorptive concentrations in the apo E4/3 group; this response was closely coupled to that of TRL cholesterol and apo E. These observations suggest that clearance of intestinal and hepatogenous TRL remnants is impaired in young men with an apo E4/3 phenotype. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/8550852/Prolonged_postprandial_responses_of_lipids_and_apolipoproteins_in_triglyceride_rich_lipoproteins_of_individuals_expressing_an_apolipoprotein_epsilon_4_allele_ L2 - https://doi.org/10.1172/JCI118408 DB - PRIME DP - Unbound Medicine ER -