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Anorectal function in fluctuating (on-off) Parkinson's disease: evaluation by combined anorectal manometry and electromyography.
Mov Disord. 1995 Sep; 10(5):650-7.MD

Abstract

Anorectal dysfunction and constipation are well recognized in Parkinson's disease and may reflect the direct involvement of the gastrointestinal tract by the primary Parkinson's disease process. We hypothesized, therefore, that anorectal function would alter in parallel with fluctuations in motor function related to on- and off-periods in Parkinson's disease, and employed combined anorectal manometry and electromyography to investigate anorectal function during both on- and off-periods in patients with Parkinson's disease. Manometric recordings revealed a deterioration in voluntary sphincter squeeze during off-periods (squeeze index, on versus off, mean +/- SEM: 46.4 +/- 11.1 versus 29.6 +/- 7.9 mm Hg, p < 0.05); correspondingly, simultaneous electromyographic (EMG) recordings showed poor recruitment of external anal sphincter and puborectalis muscles during off-periods. A hypercontractile ("paradoxical") rectosphincteric reflex response occurred during both on- and off-periods, and was associated with an increase in EMG activity in the external sphincter and/or the puborectalis muscle. These changes in manometric and EMG parameters paralleled changes in overall motor function. These findings provide further support for the involvement of the pelvic floor musculature in the Parkinson's disease process and also provide EMG correlates for some of the manometric abnormalities described in Parkinson's disease.

Authors+Show Affiliations

Section of Gastroenterology, University of Nebraska Medical Center, Omaha 68198-2000, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8552119

Citation

Ashraf, W, et al. "Anorectal Function in Fluctuating (on-off) Parkinson's Disease: Evaluation By Combined Anorectal Manometry and Electromyography." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 10, no. 5, 1995, pp. 650-7.
Ashraf W, Wszolek ZK, Pfeiffer RF, et al. Anorectal function in fluctuating (on-off) Parkinson's disease: evaluation by combined anorectal manometry and electromyography. Mov Disord. 1995;10(5):650-7.
Ashraf, W., Wszolek, Z. K., Pfeiffer, R. F., Normand, M., Maurer, K., Srb, F., Edwards, L. L., & Quigley, E. M. (1995). Anorectal function in fluctuating (on-off) Parkinson's disease: evaluation by combined anorectal manometry and electromyography. Movement Disorders : Official Journal of the Movement Disorder Society, 10(5), 650-7.
Ashraf W, et al. Anorectal Function in Fluctuating (on-off) Parkinson's Disease: Evaluation By Combined Anorectal Manometry and Electromyography. Mov Disord. 1995;10(5):650-7. PubMed PMID: 8552119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anorectal function in fluctuating (on-off) Parkinson's disease: evaluation by combined anorectal manometry and electromyography. AU - Ashraf,W, AU - Wszolek,Z K, AU - Pfeiffer,R F, AU - Normand,M, AU - Maurer,K, AU - Srb,F, AU - Edwards,L L, AU - Quigley,E M, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 650 EP - 7 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 10 IS - 5 N2 - Anorectal dysfunction and constipation are well recognized in Parkinson's disease and may reflect the direct involvement of the gastrointestinal tract by the primary Parkinson's disease process. We hypothesized, therefore, that anorectal function would alter in parallel with fluctuations in motor function related to on- and off-periods in Parkinson's disease, and employed combined anorectal manometry and electromyography to investigate anorectal function during both on- and off-periods in patients with Parkinson's disease. Manometric recordings revealed a deterioration in voluntary sphincter squeeze during off-periods (squeeze index, on versus off, mean +/- SEM: 46.4 +/- 11.1 versus 29.6 +/- 7.9 mm Hg, p < 0.05); correspondingly, simultaneous electromyographic (EMG) recordings showed poor recruitment of external anal sphincter and puborectalis muscles during off-periods. A hypercontractile ("paradoxical") rectosphincteric reflex response occurred during both on- and off-periods, and was associated with an increase in EMG activity in the external sphincter and/or the puborectalis muscle. These changes in manometric and EMG parameters paralleled changes in overall motor function. These findings provide further support for the involvement of the pelvic floor musculature in the Parkinson's disease process and also provide EMG correlates for some of the manometric abnormalities described in Parkinson's disease. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/8552119/Anorectal_function_in_fluctuating__on_off__Parkinson's_disease:_evaluation_by_combined_anorectal_manometry_and_electromyography_ L2 - https://doi.org/10.1002/mds.870100519 DB - PRIME DP - Unbound Medicine ER -