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A "combined" levodopa test as a useful method for evaluating the efficacy of dopamine agonists: application to pergolide and bromocriptine.
Mov Disord. 1995 Sep; 10(5):668-71.MD

Abstract

The efficacy of pergolide as adjunct to levodopa therapy was compared to that of bromocriptine in 12 parkinsonian patients with fluctuating motor disability and levodopa-induced dyskinesias (mean age of onset, 50.6 +/- 8 years; Hoehn and Yahr stage between II and IV; mean basal UPDRS motor score, 30.6 +/- 8.6), in a double-blind crossover study. After an 8-day habituation to each agonist, an acute challenge of a supraliminal dose of levodopa ("levodopa test") was performed in association with either 1 mg pergolide or 10 mg bromocriptine. The delay to onset and the duration of therapeutic benefit, the percentage improvement in motor disability, and the severity of onset and peak-dose dyskinesias were evaluated. Both agonists significantly increased the duration of therapeutic benefit, but pergolide more so than bromocriptine (p = 0.02). Pergolide also tended to reduce the severity of dyskinesias and was globally perceived by the patients to be more efficacious than bromocriptine on parkinsonian symptoms and fluctuations. This study illustrated the usefulness of the "levodopa test" in evaluating, objectively, the effects of dopamine agonists.

Authors+Show Affiliations

Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

8552122

Citation

Bonnet, A M., et al. "A "combined" Levodopa Test as a Useful Method for Evaluating the Efficacy of Dopamine Agonists: Application to Pergolide and Bromocriptine." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 10, no. 5, 1995, pp. 668-71.
Bonnet AM, Serre I, Marconi R, et al. A "combined" levodopa test as a useful method for evaluating the efficacy of dopamine agonists: application to pergolide and bromocriptine. Mov Disord. 1995;10(5):668-71.
Bonnet, A. M., Serre, I., Marconi, R., Agid, Y., & Dubois, B. (1995). A "combined" levodopa test as a useful method for evaluating the efficacy of dopamine agonists: application to pergolide and bromocriptine. Movement Disorders : Official Journal of the Movement Disorder Society, 10(5), 668-71.
Bonnet AM, et al. A "combined" Levodopa Test as a Useful Method for Evaluating the Efficacy of Dopamine Agonists: Application to Pergolide and Bromocriptine. Mov Disord. 1995;10(5):668-71. PubMed PMID: 8552122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A "combined" levodopa test as a useful method for evaluating the efficacy of dopamine agonists: application to pergolide and bromocriptine. AU - Bonnet,A M, AU - Serre,I, AU - Marconi,R, AU - Agid,Y, AU - Dubois,B, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 668 EP - 71 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 10 IS - 5 N2 - The efficacy of pergolide as adjunct to levodopa therapy was compared to that of bromocriptine in 12 parkinsonian patients with fluctuating motor disability and levodopa-induced dyskinesias (mean age of onset, 50.6 +/- 8 years; Hoehn and Yahr stage between II and IV; mean basal UPDRS motor score, 30.6 +/- 8.6), in a double-blind crossover study. After an 8-day habituation to each agonist, an acute challenge of a supraliminal dose of levodopa ("levodopa test") was performed in association with either 1 mg pergolide or 10 mg bromocriptine. The delay to onset and the duration of therapeutic benefit, the percentage improvement in motor disability, and the severity of onset and peak-dose dyskinesias were evaluated. Both agonists significantly increased the duration of therapeutic benefit, but pergolide more so than bromocriptine (p = 0.02). Pergolide also tended to reduce the severity of dyskinesias and was globally perceived by the patients to be more efficacious than bromocriptine on parkinsonian symptoms and fluctuations. This study illustrated the usefulness of the "levodopa test" in evaluating, objectively, the effects of dopamine agonists. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/8552122/A_"combined"_levodopa_test_as_a_useful_method_for_evaluating_the_efficacy_of_dopamine_agonists:_application_to_pergolide_and_bromocriptine_ L2 - https://doi.org/10.1002/mds.870100522 DB - PRIME DP - Unbound Medicine ER -