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Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats.
Neurosci Lett. 1995 Sep 15; 197(3):171-4.NL

Abstract

The effect of intraperitoneal administration of scopolamine (1 mg/kg) on acetylcholine (ACh) release in vivo in 3- and 24-month-old freely behaving rats was investigated in the cerebral cortex, hippocampus and striatum by means of transverse microdialysis. In the parietal cortex, the increase in ACh release after scopolamine administration was significantly greater in the old than in the young rats, reaching a maximum increase of about 600 and 300% in the old and young animals, respectively. In the hippocampus, scopolamine caused a larger increase in ACh release in the young (+900%) than in the old rats (+600%). In the striatum of aged rats, a 40% increase occurred only at 40 min after scopolamine administration while in the striatum of young animals the increase lasted for at least 2 h, reaching a maximum of about 100%. These findings demonstrate that the modulation of ACh release in vivo is affected in a different manner in the cerebral cortex than in the hippocampus and striatum by aging.

Authors+Show Affiliations

Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8552291

Citation

Scali, C, et al. "Peripherally Injected Scopolamine Differentially Modulates Acetylcholine Release in Vivo in the Young and Aged Rats." Neuroscience Letters, vol. 197, no. 3, 1995, pp. 171-4.
Scali C, Vannucchi MG, Pepeu G, et al. Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats. Neurosci Lett. 1995;197(3):171-4.
Scali, C., Vannucchi, M. G., Pepeu, G., & Casamenti, F. (1995). Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats. Neuroscience Letters, 197(3), 171-4.
Scali C, et al. Peripherally Injected Scopolamine Differentially Modulates Acetylcholine Release in Vivo in the Young and Aged Rats. Neurosci Lett. 1995 Sep 15;197(3):171-4. PubMed PMID: 8552291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats. AU - Scali,C, AU - Vannucchi,M G, AU - Pepeu,G, AU - Casamenti,F, PY - 1995/9/15/pubmed PY - 1995/9/15/medline PY - 1995/9/15/entrez SP - 171 EP - 4 JF - Neuroscience letters JO - Neurosci Lett VL - 197 IS - 3 N2 - The effect of intraperitoneal administration of scopolamine (1 mg/kg) on acetylcholine (ACh) release in vivo in 3- and 24-month-old freely behaving rats was investigated in the cerebral cortex, hippocampus and striatum by means of transverse microdialysis. In the parietal cortex, the increase in ACh release after scopolamine administration was significantly greater in the old than in the young rats, reaching a maximum increase of about 600 and 300% in the old and young animals, respectively. In the hippocampus, scopolamine caused a larger increase in ACh release in the young (+900%) than in the old rats (+600%). In the striatum of aged rats, a 40% increase occurred only at 40 min after scopolamine administration while in the striatum of young animals the increase lasted for at least 2 h, reaching a maximum of about 100%. These findings demonstrate that the modulation of ACh release in vivo is affected in a different manner in the cerebral cortex than in the hippocampus and striatum by aging. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/8552291/Peripherally_injected_scopolamine_differentially_modulates_acetylcholine_release_in_vivo_in_the_young_and_aged_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/030439409511914I DB - PRIME DP - Unbound Medicine ER -