Tags

Type your tag names separated by a space and hit enter

Proliferation tissue polypeptide antigen distinguishes malignant mucinous cystadenocarcinomas from benign cystic tumors and pseudocysts.
Am J Surg. 1996 Jan; 171(1):126-9; discussion 129-30.AJ

Abstract

BACKGROUND

Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous cystic tumors, some of which are malignant. Previous studies have shown that malignant mucinous tumors differ from benign pancreatic cysts in proliferative activity, secretion of tumor markers, and expression of growth factor receptors. Analysis of aspirated cyst fluid for tumor markers, viscosity, and cytologic examination has been proposed as an aid to preoperative differential diagnosis. Tissue polypeptide antigen (TPA) is a soluble proliferation antigen produced by rapidly dividing tissues, including conventional ductal pancreatic carcinoma. TPA levels in pancreatic cyst fluids have not been reported.

METHODS

Tissue polypeptide antigen levels were determined in 46 pancreatic cyst fluids using a commercial immunoassay technique.

RESULTS

Mucinous cystadenocarcinomas exhibited significantly higher levels of cyst fluid TPA than benign cystic lesions, including pseudocysts, serous cystadenomas, and benign mucinous cystadenomas (mean 910,672 U/mL, median 300,900 U/mL, range 16,600 to 4,210,000 U/mL for malignant mucinous cystadenocarcinomas; versus mean 16,082 U/mL, median 2,455 U/mL, range 0 to 155,000 U/mL for benign cystic lesions considered as a group; P < 0.0002). In 75% of the malignant cysts, the TPA values were in excess of 100,000 U/mL. Pseudocysts exhibited the lowest TPA levels (mean 2,108 U/mL, median 604 U/mL, range 0 to 20,240 U/mL) and were significantly lower than the values observed in cystic tumors (P < 0.0005). Serous and benign mucinous tumors had intermediate levels of TPA.

CONCLUSIONS

Elevated levels of the proliferation antigen TPA in malignant pancreatic cysts correlate with earlier observations of increased proliferative activity and overexpression of growth factor receptors in these tumors. The TPA measurement may be a useful addition to previously reported cyst fluid markers to aid in preoperative differential diagnosis. Markedly elevated or very low values indicate a malignant or benign cyst, respectively.

Authors+Show Affiliations

Department of Pathology, Massachusetts General Hospital, Boston 02114, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8554126

Citation

Yang, J M., et al. "Proliferation Tissue Polypeptide Antigen Distinguishes Malignant Mucinous Cystadenocarcinomas From Benign Cystic Tumors and Pseudocysts." American Journal of Surgery, vol. 171, no. 1, 1996, pp. 126-9; discussion 129-30.
Yang JM, Southern JF, Warshaw AL, et al. Proliferation tissue polypeptide antigen distinguishes malignant mucinous cystadenocarcinomas from benign cystic tumors and pseudocysts. Am J Surg. 1996;171(1):126-9; discussion 129-30.
Yang, J. M., Southern, J. F., Warshaw, A. L., & Lewandrowski, K. B. (1996). Proliferation tissue polypeptide antigen distinguishes malignant mucinous cystadenocarcinomas from benign cystic tumors and pseudocysts. American Journal of Surgery, 171(1), 126-9; discussion 129-30.
Yang JM, et al. Proliferation Tissue Polypeptide Antigen Distinguishes Malignant Mucinous Cystadenocarcinomas From Benign Cystic Tumors and Pseudocysts. Am J Surg. 1996;171(1):126-9; discussion 129-30. PubMed PMID: 8554126.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proliferation tissue polypeptide antigen distinguishes malignant mucinous cystadenocarcinomas from benign cystic tumors and pseudocysts. AU - Yang,J M, AU - Southern,J F, AU - Warshaw,A L, AU - Lewandrowski,K B, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 126-9; discussion 129-30 JF - American journal of surgery JO - Am J Surg VL - 171 IS - 1 N2 - BACKGROUND: Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous cystic tumors, some of which are malignant. Previous studies have shown that malignant mucinous tumors differ from benign pancreatic cysts in proliferative activity, secretion of tumor markers, and expression of growth factor receptors. Analysis of aspirated cyst fluid for tumor markers, viscosity, and cytologic examination has been proposed as an aid to preoperative differential diagnosis. Tissue polypeptide antigen (TPA) is a soluble proliferation antigen produced by rapidly dividing tissues, including conventional ductal pancreatic carcinoma. TPA levels in pancreatic cyst fluids have not been reported. METHODS: Tissue polypeptide antigen levels were determined in 46 pancreatic cyst fluids using a commercial immunoassay technique. RESULTS: Mucinous cystadenocarcinomas exhibited significantly higher levels of cyst fluid TPA than benign cystic lesions, including pseudocysts, serous cystadenomas, and benign mucinous cystadenomas (mean 910,672 U/mL, median 300,900 U/mL, range 16,600 to 4,210,000 U/mL for malignant mucinous cystadenocarcinomas; versus mean 16,082 U/mL, median 2,455 U/mL, range 0 to 155,000 U/mL for benign cystic lesions considered as a group; P < 0.0002). In 75% of the malignant cysts, the TPA values were in excess of 100,000 U/mL. Pseudocysts exhibited the lowest TPA levels (mean 2,108 U/mL, median 604 U/mL, range 0 to 20,240 U/mL) and were significantly lower than the values observed in cystic tumors (P < 0.0005). Serous and benign mucinous tumors had intermediate levels of TPA. CONCLUSIONS: Elevated levels of the proliferation antigen TPA in malignant pancreatic cysts correlate with earlier observations of increased proliferative activity and overexpression of growth factor receptors in these tumors. The TPA measurement may be a useful addition to previously reported cyst fluid markers to aid in preoperative differential diagnosis. Markedly elevated or very low values indicate a malignant or benign cyst, respectively. SN - 0002-9610 UR - https://www.unboundmedicine.com/medline/citation/8554126/Proliferation_tissue_polypeptide_antigen_distinguishes_malignant_mucinous_cystadenocarcinomas_from_benign_cystic_tumors_and_pseudocysts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9610(99)80086-5 DB - PRIME DP - Unbound Medicine ER -