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Differentiation of cows' milk intolerance and gastro-oesophageal reflux.
Arch Dis Child 1995; 73(5):439-42AD

Abstract

The aim of this study was to compare a non-invasive test of small bowel permeability with a more invasive approach involving endoscopy, mucosal biopsy, and oesophageal pH monitoring for rapidly differentiating gastro-oesophageal reflux (GOR) and cows' milk intolerance in 25 infants with persistent vomiting. Each subject underwent a cellobiose/mannitol permeability study, upper gastrointestinal endoscopy with oesophageal and small bowel biopsies, and a 24 hour pH study. Reflux disease and/or cows' milk intolerance was responsible for vomiting in 24 (96%) of the subjects. Sixteen (64%) of the infants had GOR alone, four (16%) had GOR and cows' milk intolerance, and four (16%) had cows' milk intolerance alone. Morphometric analysis of small bowel biopsies was abnormal in 19% of the patients with GOR alone and in 67% with cows' milk intolerance with or without GOR. The permeability test was abnormal in only 6% of the patients with GOR but in 100% with GOR and cows' milk intolerance and in 100% with cows' milk intolerance alone. The non-invasive permeability study aimed at rapid determination of cows' milk intolerance should pre-empt a more invasive approach in the evaluation of infants with persistent vomiting.

Authors+Show Affiliations

Department of Paediatrics, University Federico II, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8554363

Citation

Staiano, A, et al. "Differentiation of Cows' Milk Intolerance and Gastro-oesophageal Reflux." Archives of Disease in Childhood, vol. 73, no. 5, 1995, pp. 439-42.
Staiano A, Troncone R, Simeone D, et al. Differentiation of cows' milk intolerance and gastro-oesophageal reflux. Arch Dis Child. 1995;73(5):439-42.
Staiano, A., Troncone, R., Simeone, D., Mayer, M., Finelli, E., Cella, A., & Auricchio, S. (1995). Differentiation of cows' milk intolerance and gastro-oesophageal reflux. Archives of Disease in Childhood, 73(5), pp. 439-42.
Staiano A, et al. Differentiation of Cows' Milk Intolerance and Gastro-oesophageal Reflux. Arch Dis Child. 1995;73(5):439-42. PubMed PMID: 8554363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differentiation of cows' milk intolerance and gastro-oesophageal reflux. AU - Staiano,A, AU - Troncone,R, AU - Simeone,D, AU - Mayer,M, AU - Finelli,E, AU - Cella,A, AU - Auricchio,S, PY - 1995/11/1/pubmed PY - 1995/11/1/medline PY - 1995/11/1/entrez SP - 439 EP - 42 JF - Archives of disease in childhood JO - Arch. Dis. Child. VL - 73 IS - 5 N2 - The aim of this study was to compare a non-invasive test of small bowel permeability with a more invasive approach involving endoscopy, mucosal biopsy, and oesophageal pH monitoring for rapidly differentiating gastro-oesophageal reflux (GOR) and cows' milk intolerance in 25 infants with persistent vomiting. Each subject underwent a cellobiose/mannitol permeability study, upper gastrointestinal endoscopy with oesophageal and small bowel biopsies, and a 24 hour pH study. Reflux disease and/or cows' milk intolerance was responsible for vomiting in 24 (96%) of the subjects. Sixteen (64%) of the infants had GOR alone, four (16%) had GOR and cows' milk intolerance, and four (16%) had cows' milk intolerance alone. Morphometric analysis of small bowel biopsies was abnormal in 19% of the patients with GOR alone and in 67% with cows' milk intolerance with or without GOR. The permeability test was abnormal in only 6% of the patients with GOR but in 100% with GOR and cows' milk intolerance and in 100% with cows' milk intolerance alone. The non-invasive permeability study aimed at rapid determination of cows' milk intolerance should pre-empt a more invasive approach in the evaluation of infants with persistent vomiting. SN - 1468-2044 UR - https://www.unboundmedicine.com/medline/citation/8554363/Differentiation_of_cows'_milk_intolerance_and_gastro_oesophageal_reflux_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8554363.ui DB - PRIME DP - Unbound Medicine ER -