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Cancer marker assessment: case report on salivary and urinary CEA.
In Vivo. 1995 Jul-Aug; 9(4):311-4.V

Abstract

A circadian rhythm is demonstrated for salivary CEA in a clinically healthy man who collected unstimulated saliva samples around the clock for 4 days. Its acrophase occurs around 07:00, slightly later than for patients with colon cancer. A circadian rhythm of borderline statistical significance is found for the urinary excretion rate of CEA determined during the same span by this patient. It has an acrophase occurring around 15:00, differing from that of salivary CEA. Although CEA may have only limited value to assess tumor burden, even when determined in blood, rhythm characteristics of tumor markers such as CEA await applications for guiding treatment timing and for detecting earliest chronome alterations not only in the case of an overt cancer but as a feature of predisease and/or disease risk elevation.

Authors+Show Affiliations

Chronobiology Laboratories, University of Minnesota, Minneapolis 55455, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8555430

Citation

Halberg, F, et al. "Cancer Marker Assessment: Case Report On Salivary and Urinary CEA." In Vivo (Athens, Greece), vol. 9, no. 4, 1995, pp. 311-4.
Halberg F, Haus E, Lakatua DJ, et al. Cancer marker assessment: case report on salivary and urinary CEA. In Vivo. 1995;9(4):311-4.
Halberg, F., Haus, E., Lakatua, D. J., Antinozzi, R., & Cornélissen, G. (1995). Cancer marker assessment: case report on salivary and urinary CEA. In Vivo (Athens, Greece), 9(4), 311-4.
Halberg F, et al. Cancer Marker Assessment: Case Report On Salivary and Urinary CEA. In Vivo. 1995 Jul-Aug;9(4):311-4. PubMed PMID: 8555430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cancer marker assessment: case report on salivary and urinary CEA. AU - Halberg,F, AU - Haus,E, AU - Lakatua,D J, AU - Antinozzi,R, AU - Cornélissen,G, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 311 EP - 4 JF - In vivo (Athens, Greece) JO - In Vivo VL - 9 IS - 4 N2 - A circadian rhythm is demonstrated for salivary CEA in a clinically healthy man who collected unstimulated saliva samples around the clock for 4 days. Its acrophase occurs around 07:00, slightly later than for patients with colon cancer. A circadian rhythm of borderline statistical significance is found for the urinary excretion rate of CEA determined during the same span by this patient. It has an acrophase occurring around 15:00, differing from that of salivary CEA. Although CEA may have only limited value to assess tumor burden, even when determined in blood, rhythm characteristics of tumor markers such as CEA await applications for guiding treatment timing and for detecting earliest chronome alterations not only in the case of an overt cancer but as a feature of predisease and/or disease risk elevation. SN - 0258-851X UR - https://www.unboundmedicine.com/medline/citation/8555430/Cancer_marker_assessment:_case_report_on_salivary_and_urinary_CEA_ DB - PRIME DP - Unbound Medicine ER -