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Spectral differences between epitopes in the cronomes of salivary CA130 and CA125.
In Vivo. 1995 Jul-Aug; 9(4):341-6.V

Abstract

Ovarian tumor markers CA125 and CA130 are here investigated in the search for harbingers of an elevated cancer risk or pre-cancer. A circadian rhythm of large amplitude is demonstrated for salivary CA125 and CA130 of a clinically healthy 28-year-old woman (AP). The circadian rhythms of both markers found in AP have a pattern similar to that of a patient (EH) with a müllerian cancer involving the ovary, with high values in the early morning and low values in the afternoon. Whereas acrophases occur approximately at the same circadian stage in both AP and EH, the MESOR and circadian amplitude are higher in EH as compared to AP. The circadian rhythm of salivary CA130 of AP is similar to that of other clinically healthy women. CA130 concentrations are lower than CA125 concentrations in unstimulated saliva (before rinsing of the mouth) in this clinically healthy woman (AP), and in other women studied herein. This difference between CA130 and CA125 concentrations is observed irrespective of circadian stage and irrespective of the concentration range of CA125 at the outset. After rinsing of the mouth, a statistically significant decrease in both CA130 and CA125 concentration is observed in AP and in another healty woman (GC) who collected saliva both before and after rinsing of the mouth.

Authors+Show Affiliations

Faculty of Veterinary Medicine, University Complutense of Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8555433

Citation

Portela, A, et al. "Spectral Differences Between Epitopes in the Cronomes of Salivary CA130 and CA125." In Vivo (Athens, Greece), vol. 9, no. 4, 1995, pp. 341-6.
Portela A, Cornélissen G, Halberg F, et al. Spectral differences between epitopes in the cronomes of salivary CA130 and CA125. In Vivo. 1995;9(4):341-6.
Portela, A., Cornélissen, G., Halberg, F., Bast, R. C., Fujii, S., Xu, F., Yu, Y., Takagi, M., Halberg, J., & Halberg, F. (1995). Spectral differences between epitopes in the cronomes of salivary CA130 and CA125. In Vivo (Athens, Greece), 9(4), 341-6.
Portela A, et al. Spectral Differences Between Epitopes in the Cronomes of Salivary CA130 and CA125. In Vivo. 1995 Jul-Aug;9(4):341-6. PubMed PMID: 8555433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spectral differences between epitopes in the cronomes of salivary CA130 and CA125. A1 - Portela,A, AU - Cornélissen,G, AU - Halberg,F, AU - Bast,R C,Jr AU - Fujii,S, AU - Xu,F, AU - Yu,Y, AU - Takagi,M, AU - Halberg,J, AU - Halberg,F, PY - 1995/7/1/pubmed PY - 2001/3/28/medline PY - 1995/7/1/entrez SP - 341 EP - 6 JF - In vivo (Athens, Greece) JO - In Vivo VL - 9 IS - 4 N2 - Ovarian tumor markers CA125 and CA130 are here investigated in the search for harbingers of an elevated cancer risk or pre-cancer. A circadian rhythm of large amplitude is demonstrated for salivary CA125 and CA130 of a clinically healthy 28-year-old woman (AP). The circadian rhythms of both markers found in AP have a pattern similar to that of a patient (EH) with a müllerian cancer involving the ovary, with high values in the early morning and low values in the afternoon. Whereas acrophases occur approximately at the same circadian stage in both AP and EH, the MESOR and circadian amplitude are higher in EH as compared to AP. The circadian rhythm of salivary CA130 of AP is similar to that of other clinically healthy women. CA130 concentrations are lower than CA125 concentrations in unstimulated saliva (before rinsing of the mouth) in this clinically healthy woman (AP), and in other women studied herein. This difference between CA130 and CA125 concentrations is observed irrespective of circadian stage and irrespective of the concentration range of CA125 at the outset. After rinsing of the mouth, a statistically significant decrease in both CA130 and CA125 concentration is observed in AP and in another healty woman (GC) who collected saliva both before and after rinsing of the mouth. SN - 0258-851X UR - https://www.unboundmedicine.com/medline/citation/8555433/Spectral_differences_between_epitopes_in_the_cronomes_of_salivary_CA130_and_CA125_ DB - PRIME DP - Unbound Medicine ER -