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Toward salivary-urinary chronosensitivity testing: chronomes of OVX1, M-CSF and CA130.
In Vivo. 1995 Jul-Aug; 9(4):407-12.V

Abstract

Several rhythmic components were previously mapped for salivary and/or urinary CA125 and CA130. On the background of such reference standards, OVX1 and M-CSF were assayed on 242 urine samples and 160 saliva samples provided by a 71-year-old patient with a Müllerian/ovarian adenocarcinoma. Serum OVX1 correlates with serum CA125 (P = 0.002); when circulating CA125 concentrations decreased (from 122 to 14 U/ml), the urinary excretion rate of OVX1 decreased (P = 0.005), whereas the urinary excretion rate of CA125 increased (P < 0.001). Salivary OVX1 and urinary M-CSF show ultradian variations (with a frequency of one cycle in 14-17 hours), which could be utilized to guide treatment timing targeted first to optimize treatment efficacy and as a second consideration to minimize treatment toxicity.

Links

clones/clone libraries

Authors+Show Affiliations

Xu F
Duke University Medical Center, Durham, North Carolina, USA.
Yu Y
No affiliation info available
Bast RC
No affiliation info available
Cornélissen G
No affiliation info available
Fujii S
No affiliation info available
Takagi M
No affiliation info available
O'Brien T
No affiliation info available
Halberg F
No affiliation info available

MeSH

AgedAntigens, Tumor-Associated, CarbohydrateBiomarkers, TumorChronobiology PhenomenaCircadian RhythmFemaleGlycoproteinsHumansMacrophage Colony-Stimulating FactorProteinsSaliva

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8555442

Citation

Xu, F, et al. "Toward Salivary-urinary Chronosensitivity Testing: Chronomes of OVX1, M-CSF and CA130." In Vivo (Athens, Greece), vol. 9, no. 4, 1995, pp. 407-12.
Xu F, Yu Y, Bast RC, et al. Toward salivary-urinary chronosensitivity testing: chronomes of OVX1, M-CSF and CA130. In Vivo. 1995;9(4):407-12.
Xu, F., Yu, Y., Bast, R. C., Cornélissen, G., Fujii, S., Takagi, M., O'Brien, T., & Halberg, F. (1995). Toward salivary-urinary chronosensitivity testing: chronomes of OVX1, M-CSF and CA130. In Vivo (Athens, Greece), 9(4), 407-12.
Xu F, et al. Toward Salivary-urinary Chronosensitivity Testing: Chronomes of OVX1, M-CSF and CA130. In Vivo. 1995 Jul-Aug;9(4):407-12. PubMed PMID: 8555442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toward salivary-urinary chronosensitivity testing: chronomes of OVX1, M-CSF and CA130. AU - Xu,F, AU - Yu,Y, AU - Bast,R C,Jr AU - Cornélissen,G, AU - Fujii,S, AU - Takagi,M, AU - O'Brien,T, AU - Halberg,F, PY - 1995/7/1/pubmed PY - 2001/3/28/medline PY - 1995/7/1/entrez SP - 407 EP - 12 JF - In vivo (Athens, Greece) JO - In Vivo VL - 9 IS - 4 N2 - Several rhythmic components were previously mapped for salivary and/or urinary CA125 and CA130. On the background of such reference standards, OVX1 and M-CSF were assayed on 242 urine samples and 160 saliva samples provided by a 71-year-old patient with a Müllerian/ovarian adenocarcinoma. Serum OVX1 correlates with serum CA125 (P = 0.002); when circulating CA125 concentrations decreased (from 122 to 14 U/ml), the urinary excretion rate of OVX1 decreased (P = 0.005), whereas the urinary excretion rate of CA125 increased (P < 0.001). Salivary OVX1 and urinary M-CSF show ultradian variations (with a frequency of one cycle in 14-17 hours), which could be utilized to guide treatment timing targeted first to optimize treatment efficacy and as a second consideration to minimize treatment toxicity. SN - 0258-851X UR - https://www.unboundmedicine.com/medline/citation/8555442/Toward_salivary_urinary_chronosensitivity_testing:_chronomes_of_OVX1_M_CSF_and_CA130_ L2 - https://antibodies.cancer.gov/detail/CPTC-CSF1-1 DB - PRIME DP - Unbound Medicine ER -