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Evaluation of neuromuscular effects and antagonism of rocuronium bromide: a preliminary report.
Eur J Anaesthesiol Suppl. 1995 Sep; 11:65-8.EJ

Abstract

Twenty ASA I-II patients received either 2 or 3 x ED95 doses of rocuronium bromide during nitrous oxide, oxygen, propofol, fentanyl-based anaesthesia. The mean times to maximum block were 98 s and 74 s and the mean duration of clinical relaxation (recovery to 25% T1) was 35 min and 46 min following 620 micrograms kg-1 and 930 micrograms kg-1, respectively. Neuromuscular blockade was antagonized with either neostigmine or edrophonium from a twitch height of 25%. Although there was no significant difference between the recovery times neostigmine appeared to give more consistent antagonism of rocuronium-induced blockade.

Authors+Show Affiliations

Anaesthetics Unit, Royal London Hospital, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8557009

Citation

Davis, L, et al. "Evaluation of Neuromuscular Effects and Antagonism of Rocuronium Bromide: a Preliminary Report." European Journal of Anaesthesiology. Supplement, vol. 11, 1995, pp. 65-8.
Davis L, Jayarajah MJ, Toner CC, et al. Evaluation of neuromuscular effects and antagonism of rocuronium bromide: a preliminary report. Eur J Anaesthesiol Suppl. 1995;11:65-8.
Davis, L., Jayarajah, M. J., Toner, C. C., & Flynn, P. J. (1995). Evaluation of neuromuscular effects and antagonism of rocuronium bromide: a preliminary report. European Journal of Anaesthesiology. Supplement, 11, 65-8.
Davis L, et al. Evaluation of Neuromuscular Effects and Antagonism of Rocuronium Bromide: a Preliminary Report. Eur J Anaesthesiol Suppl. 1995;11:65-8. PubMed PMID: 8557009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of neuromuscular effects and antagonism of rocuronium bromide: a preliminary report. AU - Davis,L, AU - Jayarajah,M J, AU - Toner,C C, AU - Flynn,P J, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 65 EP - 8 JF - European journal of anaesthesiology. Supplement JO - Eur J Anaesthesiol Suppl VL - 11 N2 - Twenty ASA I-II patients received either 2 or 3 x ED95 doses of rocuronium bromide during nitrous oxide, oxygen, propofol, fentanyl-based anaesthesia. The mean times to maximum block were 98 s and 74 s and the mean duration of clinical relaxation (recovery to 25% T1) was 35 min and 46 min following 620 micrograms kg-1 and 930 micrograms kg-1, respectively. Neuromuscular blockade was antagonized with either neostigmine or edrophonium from a twitch height of 25%. Although there was no significant difference between the recovery times neostigmine appeared to give more consistent antagonism of rocuronium-induced blockade. SN - 0952-1941 UR - https://www.unboundmedicine.com/medline/citation/8557009/Evaluation_of_neuromuscular_effects_and_antagonism_of_rocuronium_bromide:_a_preliminary_report_ DB - PRIME DP - Unbound Medicine ER -