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Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis.
J Nutr. 1996 Jan; 126(1):161-7.JN

Abstract

The purpose of this study was to examine whether soybean protein isolate prevents bone loss induced by ovarian hormone deficiency. Thirty-two 95-d-old Sprague-Dawley rats were randomly assigned to four treatment groups [sham-operated (sham); ovariectomized (ovx); ovx+soybean; ovx + 17 beta-estradiol (E2)] and killed after 30 d. Rats in the sham, ovx and ovx + 17 beta-estradiol groups were fed a casein-based diet, and the soybean group was fed soybean protein isolate instead of casein; the diets were otherwise comparable. Rats in the ovx group had significantly lower densities of the right femur (P < 0.001) and the fourth lumbar vertebra (P < 0.05) than rats in the sham group. These lower bone densities were not observed in animals receiving 17 beta-estradiol or fed soybean. The ovx group also had significantly (P < 0.01) greater serum concentrations of 1,25-dihydroxycholecalciferol than the other three groups. Our findings suggest that dietary soybean protein is effective in preventing bone loss due to ovarian hormone deficiency. Because serum activities of both alkaline phosphatase and tartrate-resistant acid phosphatase were significantly greater in the ovx group and in the ovx + soybean group but not in the group receiving 17 beta-estradiol, compared with sham animals, this confirms that ovariectomy enhances and 17 beta-estradiol suppresses the rate of bone turnover. Despite the higher rate of bone turnover in the soybean-fed animals, the vertebral and femoral bone densities of these rats were significantly greater than those of rats in the ovx group, suggesting that formation exceeded resorption. Further studies are needed to clarify whether this protective effect on bone is due to the protein itself or to the presence of isoflavones in soybean protein.

Authors+Show Affiliations

Department of Human Nutrition and Dietetics, University of Illinois at Chicago 60612, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8558297

Citation

Arjmandi, B H., et al. "Dietary Soybean Protein Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis." The Journal of Nutrition, vol. 126, no. 1, 1996, pp. 161-7.
Arjmandi BH, Alekel L, Hollis BW, et al. Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. J Nutr. 1996;126(1):161-7.
Arjmandi, B. H., Alekel, L., Hollis, B. W., Amin, D., Stacewicz-Sapuntzakis, M., Guo, P., & Kukreja, S. C. (1996). Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. The Journal of Nutrition, 126(1), 161-7.
Arjmandi BH, et al. Dietary Soybean Protein Prevents Bone Loss in an Ovariectomized Rat Model of Osteoporosis. J Nutr. 1996;126(1):161-7. PubMed PMID: 8558297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis. AU - Arjmandi,B H, AU - Alekel,L, AU - Hollis,B W, AU - Amin,D, AU - Stacewicz-Sapuntzakis,M, AU - Guo,P, AU - Kukreja,S C, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 161 EP - 7 JF - The Journal of nutrition JO - J. Nutr. VL - 126 IS - 1 N2 - The purpose of this study was to examine whether soybean protein isolate prevents bone loss induced by ovarian hormone deficiency. Thirty-two 95-d-old Sprague-Dawley rats were randomly assigned to four treatment groups [sham-operated (sham); ovariectomized (ovx); ovx+soybean; ovx + 17 beta-estradiol (E2)] and killed after 30 d. Rats in the sham, ovx and ovx + 17 beta-estradiol groups were fed a casein-based diet, and the soybean group was fed soybean protein isolate instead of casein; the diets were otherwise comparable. Rats in the ovx group had significantly lower densities of the right femur (P < 0.001) and the fourth lumbar vertebra (P < 0.05) than rats in the sham group. These lower bone densities were not observed in animals receiving 17 beta-estradiol or fed soybean. The ovx group also had significantly (P < 0.01) greater serum concentrations of 1,25-dihydroxycholecalciferol than the other three groups. Our findings suggest that dietary soybean protein is effective in preventing bone loss due to ovarian hormone deficiency. Because serum activities of both alkaline phosphatase and tartrate-resistant acid phosphatase were significantly greater in the ovx group and in the ovx + soybean group but not in the group receiving 17 beta-estradiol, compared with sham animals, this confirms that ovariectomy enhances and 17 beta-estradiol suppresses the rate of bone turnover. Despite the higher rate of bone turnover in the soybean-fed animals, the vertebral and femoral bone densities of these rats were significantly greater than those of rats in the ovx group, suggesting that formation exceeded resorption. Further studies are needed to clarify whether this protective effect on bone is due to the protein itself or to the presence of isoflavones in soybean protein. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/8558297/Dietary_soybean_protein_prevents_bone_loss_in_an_ovariectomized_rat_model_of_osteoporosis_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/126.1.161 DB - PRIME DP - Unbound Medicine ER -