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Effect of magnesium deficiency on triacylglycerol-rich lipoprotein and tissue susceptibility to peroxidation in relation to vitamin E content.
Br J Nutr. 1995 Dec; 74(6):849-56.BJ

Abstract

Given the current interest in the cardiovascular complications of Mg deficiency, the aim of the present experiment was to investigate the effect of Mg deficiency on the time-course of lipoprotein oxidation and to assess whether short-term Mg deficiency results in vitamin E depletion that predisposes lipoproteins and tissues to subsequent oxidation. Weanling rats were pair-fed for 8 d with control and Mg-deficient diets respectively. Plasma triacylglycerol and alpha-tocopherol levels were significantly greater in Mg-deficient rats compared with control animals. The increase in plasma apolipoprotein B concentration indicated that a corresponding increase in plasma triacylglycerol-rich lipoproteins (TGRLP) occurred in Mg-deficient animals. Hyperlipaemia was associated with modifications in the composition of TGRLP. The proportion of triacylglycerols was elevated whereas that of cholesterol and protein was reduced, and Mg deficiency resulted in a slight significant reduction in alpha-tocopherol content. When the TGRLP fractions were subjected to in vitro Cu-induced oxidation the lipoprotein fractions from Mg-deficient rats were more susceptible to oxidative damage than lipoprotein fractions from control rats. Mg deficiency did not modify the alpha-tocopherol content of liver, heart and skeletal muscle. However, after exposure of tissue homogenates to Fe-induced lipid peroxidation, thiobarbituric acid-reactive substances were significantly higher in tissues from Mg-deficient rats compared with those from control rats. These results complement previous findings, showing that Mg deficiency increases the susceptibility of TGRLP and tissues to peroxidation and suggest that oxidative damage is not the result of a decrease in vitamin E antioxidant status.

Authors+Show Affiliations

Centre de Recherche en Nutrition Humaine, Laboratoire des Maladies Métaboliques, INRA, St-Genès-Champanelle, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8562571

Citation

Gueux, E, et al. "Effect of Magnesium Deficiency On Triacylglycerol-rich Lipoprotein and Tissue Susceptibility to Peroxidation in Relation to Vitamin E Content." The British Journal of Nutrition, vol. 74, no. 6, 1995, pp. 849-56.
Gueux E, Azais-Braesco V, Bussière L, et al. Effect of magnesium deficiency on triacylglycerol-rich lipoprotein and tissue susceptibility to peroxidation in relation to vitamin E content. Br J Nutr. 1995;74(6):849-56.
Gueux, E., Azais-Braesco, V., Bussière, L., Grolier, P., Mazur, A., & Rayssiguier, Y. (1995). Effect of magnesium deficiency on triacylglycerol-rich lipoprotein and tissue susceptibility to peroxidation in relation to vitamin E content. The British Journal of Nutrition, 74(6), 849-56.
Gueux E, et al. Effect of Magnesium Deficiency On Triacylglycerol-rich Lipoprotein and Tissue Susceptibility to Peroxidation in Relation to Vitamin E Content. Br J Nutr. 1995;74(6):849-56. PubMed PMID: 8562571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of magnesium deficiency on triacylglycerol-rich lipoprotein and tissue susceptibility to peroxidation in relation to vitamin E content. AU - Gueux,E, AU - Azais-Braesco,V, AU - Bussière,L, AU - Grolier,P, AU - Mazur,A, AU - Rayssiguier,Y, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 849 EP - 56 JF - The British journal of nutrition JO - Br J Nutr VL - 74 IS - 6 N2 - Given the current interest in the cardiovascular complications of Mg deficiency, the aim of the present experiment was to investigate the effect of Mg deficiency on the time-course of lipoprotein oxidation and to assess whether short-term Mg deficiency results in vitamin E depletion that predisposes lipoproteins and tissues to subsequent oxidation. Weanling rats were pair-fed for 8 d with control and Mg-deficient diets respectively. Plasma triacylglycerol and alpha-tocopherol levels were significantly greater in Mg-deficient rats compared with control animals. The increase in plasma apolipoprotein B concentration indicated that a corresponding increase in plasma triacylglycerol-rich lipoproteins (TGRLP) occurred in Mg-deficient animals. Hyperlipaemia was associated with modifications in the composition of TGRLP. The proportion of triacylglycerols was elevated whereas that of cholesterol and protein was reduced, and Mg deficiency resulted in a slight significant reduction in alpha-tocopherol content. When the TGRLP fractions were subjected to in vitro Cu-induced oxidation the lipoprotein fractions from Mg-deficient rats were more susceptible to oxidative damage than lipoprotein fractions from control rats. Mg deficiency did not modify the alpha-tocopherol content of liver, heart and skeletal muscle. However, after exposure of tissue homogenates to Fe-induced lipid peroxidation, thiobarbituric acid-reactive substances were significantly higher in tissues from Mg-deficient rats compared with those from control rats. These results complement previous findings, showing that Mg deficiency increases the susceptibility of TGRLP and tissues to peroxidation and suggest that oxidative damage is not the result of a decrease in vitamin E antioxidant status. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/8562571/Effect_of_magnesium_deficiency_on_triacylglycerol_rich_lipoprotein_and_tissue_susceptibility_to_peroxidation_in_relation_to_vitamin_E_content_ L2 - https://www.cambridge.org/core/product/identifier/S0007114595001905/type/journal_article DB - PRIME DP - Unbound Medicine ER -