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First bleeding episode from oesophageal varices in cirrhotic patients: a prospective study of endoscopic predictive factors.
Ital J Gastroenterol. 1995 Sep; 27(7):345-8.IJ

Abstract

Two hundred patients affected by liver cirrhosis and oesophageal varices were studied in 9 Gastrointestinal Units in Lombardy (Northern Italy) in order to assess factors possibly related to variceal bleeding. Only patients without any previous episode of gastrointestinal bleeding were included in the prospective evaluation. For each patient demographic data, aetiology of cirrhosis, various clinical and biochemical parameters able to group patients into the three Child-Pugh Classes, endoscopic items for calculation of Beppu's and of NIEC prognostic scores were recorded on computerized cards. Patients were regularly interviewed every three months for one year and underwent an upper gastrointestinal endoscopy at enrollment, after six months and in case of bleeding. Within the twelve-month follow-up period, 29 out of the 200 patients (14%) bled and 52 out of 200 died (26%). In 16 of the 52 patients who died (59% of bleeding patients) death was directly related to gastrointestinal bleeding. Bleeding from oesophageal varices was endoscopically proven in 19/29 patients, in another 9 bleeding was classified as from unknown source and in one patient a bleeding gastric ulcer was diagnosed. Univariate analysis of all the recorded clinical, biochemical and endoscopic parameters, performed by Chi-square method and Fisher exact test showed that the presence of RWM (p < 0.001) was the only factor significantly associated to variceal bleeding within one year. Relationship between size of varices and bleeding was very close to the statistical significance but did not achieve it (p = 0.058).

Authors+Show Affiliations

Gastrointestinal Unit, Hospital of Garbagnate Milanese, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

8563003

Citation

Colombo, E, et al. "First Bleeding Episode From Oesophageal Varices in Cirrhotic Patients: a Prospective Study of Endoscopic Predictive Factors." The Italian Journal of Gastroenterology, vol. 27, no. 7, 1995, pp. 345-8.
Colombo E, Casiraghi MA, Minoli G, et al. First bleeding episode from oesophageal varices in cirrhotic patients: a prospective study of endoscopic predictive factors. Ital J Gastroenterol. 1995;27(7):345-8.
Colombo, E., Casiraghi, M. A., Minoli, G., Prada, A., Terruzzi, V., Bortoli, A., Carnovali, M., Gullotta, R., Imperiali, G., & Comin, U. (1995). First bleeding episode from oesophageal varices in cirrhotic patients: a prospective study of endoscopic predictive factors. The Italian Journal of Gastroenterology, 27(7), 345-8.
Colombo E, et al. First Bleeding Episode From Oesophageal Varices in Cirrhotic Patients: a Prospective Study of Endoscopic Predictive Factors. Ital J Gastroenterol. 1995;27(7):345-8. PubMed PMID: 8563003.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First bleeding episode from oesophageal varices in cirrhotic patients: a prospective study of endoscopic predictive factors. A1 - Colombo,E, AU - Casiraghi,M A, AU - Minoli,G, AU - Prada,A, AU - Terruzzi,V, AU - Bortoli,A, AU - Carnovali,M, AU - Gullotta,R, AU - Imperiali,G, AU - Comin,U, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 345 EP - 8 JF - The Italian journal of gastroenterology JO - Ital J Gastroenterol VL - 27 IS - 7 N2 - Two hundred patients affected by liver cirrhosis and oesophageal varices were studied in 9 Gastrointestinal Units in Lombardy (Northern Italy) in order to assess factors possibly related to variceal bleeding. Only patients without any previous episode of gastrointestinal bleeding were included in the prospective evaluation. For each patient demographic data, aetiology of cirrhosis, various clinical and biochemical parameters able to group patients into the three Child-Pugh Classes, endoscopic items for calculation of Beppu's and of NIEC prognostic scores were recorded on computerized cards. Patients were regularly interviewed every three months for one year and underwent an upper gastrointestinal endoscopy at enrollment, after six months and in case of bleeding. Within the twelve-month follow-up period, 29 out of the 200 patients (14%) bled and 52 out of 200 died (26%). In 16 of the 52 patients who died (59% of bleeding patients) death was directly related to gastrointestinal bleeding. Bleeding from oesophageal varices was endoscopically proven in 19/29 patients, in another 9 bleeding was classified as from unknown source and in one patient a bleeding gastric ulcer was diagnosed. Univariate analysis of all the recorded clinical, biochemical and endoscopic parameters, performed by Chi-square method and Fisher exact test showed that the presence of RWM (p < 0.001) was the only factor significantly associated to variceal bleeding within one year. Relationship between size of varices and bleeding was very close to the statistical significance but did not achieve it (p = 0.058). SN - 0392-0623 UR - https://www.unboundmedicine.com/medline/citation/8563003/First_bleeding_episode_from_oesophageal_varices_in_cirrhotic_patients:_a_prospective_study_of_endoscopic_predictive_factors_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -