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Detection of Pneumocystis carinii, Mycobacterium tuberculosis, and cytomegalovirus in human immunodeficiency virus (HIV)-infected patients with hemophilia by polymerase chain reaction of induced sputum samples.
Intern Med. 1995 Oct; 34(10):976-81.IM

Abstract

The purpose of this study was to diagnose the initial stage of acute pulmonary infections due to Pneumocystis carinii (P. carinii), Mycobacterium tuberculosis (M. tuberculosis), and cytomegalovirus (CMV) by polymerase chain reaction (PCR) combined with the induced sputum method in hemophilia patients infected with human immunodeficiency virus (HIV). Induced sputum and PCR were obtained at each outpatient visit or when any respiratory symptoms were present during a one-year period. All patients with a CD4+ count of less than 200 x 10(6)/l were given prophylactics against P. carinii pneumonia (PCP). PCR was conducted 111 times in 29 patients. M. tuberculosis DNA was detected in 1 patient and CMV DNA in 4 patients. P. carinii DNA was not detected. PCR on induced sputum samples is sensitive for the rapid detection of the initial stage of respiratory events. PCP prophylaxis changes the clinical manifestations of HIV infection.

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Authors+Show Affiliations

Shimomoto H
First Department of Internal Medicine, Nagoya University School of Medicine.
Hasegawa Y
No affiliation info available
Takagi N
No affiliation info available
Ichiyama S
No affiliation info available
Takamatsu J
No affiliation info available
Saito H
No affiliation info available
Shimokata K
No affiliation info available

MeSH

AIDS-Related Opportunistic InfectionsAdolescentAdultBase SequenceCD4 Lymphocyte CountCytomegalovirusCytomegalovirus InfectionsDNA, BacterialDNA, FungalDNA, ViralHemophilia AHumansMaleMolecular Sequence DataMycobacterium tuberculosisOxygenPneumocystisPneumonia, PneumocystisPolymerase Chain ReactionSputumTuberculosis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8563099

Citation

Shimomoto, H, et al. "Detection of Pneumocystis Carinii, Mycobacterium Tuberculosis, and Cytomegalovirus in Human Immunodeficiency Virus (HIV)-infected Patients With Hemophilia By Polymerase Chain Reaction of Induced Sputum Samples." Internal Medicine (Tokyo, Japan), vol. 34, no. 10, 1995, pp. 976-81.
Shimomoto H, Hasegawa Y, Takagi N, et al. Detection of Pneumocystis carinii, Mycobacterium tuberculosis, and cytomegalovirus in human immunodeficiency virus (HIV)-infected patients with hemophilia by polymerase chain reaction of induced sputum samples. Intern Med. 1995;34(10):976-81.
Shimomoto, H., Hasegawa, Y., Takagi, N., Ichiyama, S., Takamatsu, J., Saito, H., & Shimokata, K. (1995). Detection of Pneumocystis carinii, Mycobacterium tuberculosis, and cytomegalovirus in human immunodeficiency virus (HIV)-infected patients with hemophilia by polymerase chain reaction of induced sputum samples. Internal Medicine (Tokyo, Japan), 34(10), 976-81.
Shimomoto H, et al. Detection of Pneumocystis Carinii, Mycobacterium Tuberculosis, and Cytomegalovirus in Human Immunodeficiency Virus (HIV)-infected Patients With Hemophilia By Polymerase Chain Reaction of Induced Sputum Samples. Intern Med. 1995;34(10):976-81. PubMed PMID: 8563099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of Pneumocystis carinii, Mycobacterium tuberculosis, and cytomegalovirus in human immunodeficiency virus (HIV)-infected patients with hemophilia by polymerase chain reaction of induced sputum samples. AU - Shimomoto,H, AU - Hasegawa,Y, AU - Takagi,N, AU - Ichiyama,S, AU - Takamatsu,J, AU - Saito,H, AU - Shimokata,K, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 976 EP - 81 JF - Internal medicine (Tokyo, Japan) JO - Intern Med VL - 34 IS - 10 N2 - The purpose of this study was to diagnose the initial stage of acute pulmonary infections due to Pneumocystis carinii (P. carinii), Mycobacterium tuberculosis (M. tuberculosis), and cytomegalovirus (CMV) by polymerase chain reaction (PCR) combined with the induced sputum method in hemophilia patients infected with human immunodeficiency virus (HIV). Induced sputum and PCR were obtained at each outpatient visit or when any respiratory symptoms were present during a one-year period. All patients with a CD4+ count of less than 200 x 10(6)/l were given prophylactics against P. carinii pneumonia (PCP). PCR was conducted 111 times in 29 patients. M. tuberculosis DNA was detected in 1 patient and CMV DNA in 4 patients. P. carinii DNA was not detected. PCR on induced sputum samples is sensitive for the rapid detection of the initial stage of respiratory events. PCP prophylaxis changes the clinical manifestations of HIV infection. SN - 0918-2918 UR - https://www.unboundmedicine.com/medline/citation/8563099/Detection_of_Pneumocystis_carinii_Mycobacterium_tuberculosis_and_cytomegalovirus_in_human_immunodeficiency_virus__HIV__infected_patients_with_hemophilia_by_polymerase_chain_reaction_of_induced_sputum_samples_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/internalmedicine1992/34.976?from=PubMed DB - PRIME DP - Unbound Medicine ER -