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Vanadium compounds as insulin mimics.
Met Ions Biol Syst 1995; 31:575-94MI

Abstract

That vanadium compounds act in an insulin-mimetic fashion both in vitro and in vivo has been well established. Both inorganic and organic vanadium compounds have been shown to lower plasma glucose levels, increase peripheral glucose uptake, improve insulin sensitivity, decrease plasma lipid levels, and normalize liver enzyme activities in a variety of animal models of both type I and type II diabetes. Vanadium treatment of diabetic animals does not restore plasma insulin levels but may spare pancreatic insulin. Elucidation of the mechanism(s) of action and potentiation of vanadium's insulin-mimetic effect by appropriate ligand binding would seem to be the highest priorities for future investigation.

Authors+Show Affiliations

Department of Chemistry, University of British Columbia, Vancouver, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8564818

Citation

Orvig, C, et al. "Vanadium Compounds as Insulin Mimics." Metal Ions in Biological Systems, vol. 31, 1995, pp. 575-94.
Orvig C, Thompson KH, Battell M, et al. Vanadium compounds as insulin mimics. Met Ions Biol Syst. 1995;31:575-94.
Orvig, C., Thompson, K. H., Battell, M., & McNeill, J. H. (1995). Vanadium compounds as insulin mimics. Metal Ions in Biological Systems, 31, pp. 575-94.
Orvig C, et al. Vanadium Compounds as Insulin Mimics. Met Ions Biol Syst. 1995;31:575-94. PubMed PMID: 8564818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vanadium compounds as insulin mimics. AU - Orvig,C, AU - Thompson,K H, AU - Battell,M, AU - McNeill,J H, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 575 EP - 94 JF - Metal ions in biological systems JO - Met Ions Biol Syst VL - 31 N2 - That vanadium compounds act in an insulin-mimetic fashion both in vitro and in vivo has been well established. Both inorganic and organic vanadium compounds have been shown to lower plasma glucose levels, increase peripheral glucose uptake, improve insulin sensitivity, decrease plasma lipid levels, and normalize liver enzyme activities in a variety of animal models of both type I and type II diabetes. Vanadium treatment of diabetic animals does not restore plasma insulin levels but may spare pancreatic insulin. Elucidation of the mechanism(s) of action and potentiation of vanadium's insulin-mimetic effect by appropriate ligand binding would seem to be the highest priorities for future investigation. SN - 0161-5149 UR - https://www.unboundmedicine.com/medline/citation/8564818/Vanadium_compounds_as_insulin_mimics_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -