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Age-related changes in cochlear vascular conductance in mice.
Hear Res. 1995 Jun; 86(1-2):189-94.HR

Abstract

Vascular changes contribute to age-related hearing loss but the mechanisms involved in microvascular reactivity, particularly in the aged ear, are still incompletely understood. In this study, possible age-related changes in cochlear blood flow (CBF) and vascular reactivity were studied in presbycusic mice (C57BL/6) and young, age-matched, and old controls (CBA/J) without presbycusis. Reactivity was monitored by laser Doppler flowmetry and assessed by change in cochlear vascular conductance (VC) (defined as the ratio of CBF to blood pressure) in response to round window-applied sodium nitroprusside, a vasodilating agent. Mean VC response of C57BL/6 mice differed from controls both in maximum response and in post-drug recovery time. In C57BL/6 mice, mean VC increased about 28%, in contrast to an increase of over 40% in young and age-matched CBA/J controls. A less elevated VC response, similar to that of the presbycusic mice, was shown by aged (20-21 month) controls. Also, VC response in C57BL/6 mice was sustained throughout the 60 min observation period, while response of most CBA/J controls recovered in 50 min or less. These changes suggest age-dependent, pathologically-related altered responsiveness in cochlear vascular reactivity.

Authors+Show Affiliations

Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8567416

Citation

Brown, J N., et al. "Age-related Changes in Cochlear Vascular Conductance in Mice." Hearing Research, vol. 86, no. 1-2, 1995, pp. 189-94.
Brown JN, Miller JM, Nuttall AL. Age-related changes in cochlear vascular conductance in mice. Hear Res. 1995;86(1-2):189-94.
Brown, J. N., Miller, J. M., & Nuttall, A. L. (1995). Age-related changes in cochlear vascular conductance in mice. Hearing Research, 86(1-2), 189-94.
Brown JN, Miller JM, Nuttall AL. Age-related Changes in Cochlear Vascular Conductance in Mice. Hear Res. 1995;86(1-2):189-94. PubMed PMID: 8567416.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related changes in cochlear vascular conductance in mice. AU - Brown,J N, AU - Miller,J M, AU - Nuttall,A L, PY - 1995/6/1/pubmed PY - 1995/6/1/medline PY - 1995/6/1/entrez SP - 189 EP - 94 JF - Hearing research JO - Hear. Res. VL - 86 IS - 1-2 N2 - Vascular changes contribute to age-related hearing loss but the mechanisms involved in microvascular reactivity, particularly in the aged ear, are still incompletely understood. In this study, possible age-related changes in cochlear blood flow (CBF) and vascular reactivity were studied in presbycusic mice (C57BL/6) and young, age-matched, and old controls (CBA/J) without presbycusis. Reactivity was monitored by laser Doppler flowmetry and assessed by change in cochlear vascular conductance (VC) (defined as the ratio of CBF to blood pressure) in response to round window-applied sodium nitroprusside, a vasodilating agent. Mean VC response of C57BL/6 mice differed from controls both in maximum response and in post-drug recovery time. In C57BL/6 mice, mean VC increased about 28%, in contrast to an increase of over 40% in young and age-matched CBA/J controls. A less elevated VC response, similar to that of the presbycusic mice, was shown by aged (20-21 month) controls. Also, VC response in C57BL/6 mice was sustained throughout the 60 min observation period, while response of most CBA/J controls recovered in 50 min or less. These changes suggest age-dependent, pathologically-related altered responsiveness in cochlear vascular reactivity. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/8567416/Age_related_changes_in_cochlear_vascular_conductance_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-5955(95)00070-K DB - PRIME DP - Unbound Medicine ER -